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Downloaded from
YTS.LT

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Official YIFY movies site:
YTS.LT

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Dr. Slamon? Hi.
Hello.

4
00:01:31,359 --> 00:01:34,061
It's Jamie MacGraw.
Work-Study sent me.

5
00:01:35,296 --> 00:01:37,598
Oh! My student assistant.
Right, right.

6
00:01:37,665 --> 00:01:38,966
I'm right up here
on the left.

7
00:01:39,032 --> 00:01:41,569
Okay.
Come on in.

8
00:01:41,635 --> 00:01:43,103
What are you,
biology, chem?

9
00:01:43,171 --> 00:01:45,173
No. English lit.

10
00:01:45,239 --> 00:01:46,407
You're not
a science major?

11
00:01:46,474 --> 00:01:47,841
No.

12
00:01:47,908 --> 00:01:50,311
No offense, uh...
Jamie.

13
00:01:50,378 --> 00:01:54,348
Jamie. Right. But I'm doing
scientific research here,

14
00:01:54,415 --> 00:01:59,019
and I kind of need
an assistant who
understands what I do.

15
00:01:59,086 --> 00:02:02,156
Well, this wasn't my
first choice, either,

16
00:02:02,223 --> 00:02:05,226
and no science majors
wanted this job.

17
00:02:05,293 --> 00:02:06,327
What

18
00:02:06,394 --> 00:02:07,461
No.

19
00:02:09,129 --> 00:02:10,731
Well, tell me you at least
read science fiction.

20
00:02:10,798 --> 00:02:12,032
Mmm...

21
00:02:16,437 --> 00:02:18,906
Dr. Slamon's office,
I mean, lab.

22
00:02:20,874 --> 00:02:24,645
Jamie. Oh!
Nice to meet you,
too, Mrs. Slamon.

23
00:02:24,712 --> 00:02:25,846
Hold on.

24
00:02:25,913 --> 00:02:27,981
Here.
Hi.

25
00:02:28,048 --> 00:02:31,185
No, I didn't forget.
6:30 at the latest, right?

26
00:02:31,252 --> 00:02:33,721
Okay. Me, too.
Bye-bye.

27
00:02:35,189 --> 00:02:36,857
Could you hand me that
splicer over there, please?

28
00:02:36,924 --> 00:02:38,859
Um...

29
00:02:38,926 --> 00:02:40,194
No, no, no, to the left,
to the left.
Left, left, left, left.

30
00:02:40,261 --> 00:02:41,529
Right there.
Thank you very much.

31
00:02:41,595 --> 00:02:43,864
Well, thanks anyway.

32
00:02:45,132 --> 00:02:46,367
You know what?

33
00:02:46,434 --> 00:02:48,236
I don't really need
a science major.

34
00:02:48,302 --> 00:02:50,438
I just need someone
to handle my calls,
do the paperwork.

35
00:02:50,504 --> 00:02:53,674
Whatever it takes
so I can concentrate
on my patients and HER-2.

36
00:02:53,741 --> 00:02:54,775
HER

37
00:02:54,842 --> 00:02:56,544
Yeah, it's a growth
gene I'm using to

38
00:02:56,610 --> 00:02:58,646
try and create a drug
to treat breast cancer.

39
00:02:58,712 --> 00:03:00,714
Oh! Like chemo?

40
00:03:00,781 --> 00:03:03,484
No. No, no, no.
It's nothing like chemo.

41
00:03:03,551 --> 00:03:07,355
See, chemotherapy works
on the principle
of killing cancer cells,

42
00:03:07,421 --> 00:03:08,989
and almost the patient,

43
00:03:09,056 --> 00:03:12,226
with poison and just
hoping the new cells
grow back cancer-free.

44
00:03:12,293 --> 00:03:13,727
That doesn't make
sense to me.

45
00:03:13,794 --> 00:03:15,896
What I'm trying to do
is something that's
never been done before.

46
00:03:15,963 --> 00:03:18,399
Take a sort of
super-protein from the body

47
00:03:18,466 --> 00:03:21,869
and target the bad cells
and turn them off
like a light switch.

48
00:03:21,935 --> 00:03:25,773
It won't cure the cancer,
but it'll shut it off,
which is almost as good.

49
00:03:25,839 --> 00:03:26,874
That sounds really...

50
00:03:26,940 --> 00:03:28,509
Crazy. Right, I know.

51
00:03:28,576 --> 00:03:30,110
Everyone says that,
but it's not.

52
00:03:30,177 --> 00:03:32,713
If we can learn how to
shut the bad cells off,

53
00:03:32,780 --> 00:03:35,316
that will lead us
to a cure.

54
00:03:35,383 --> 00:03:37,217
And, just so you know,

55
00:03:37,285 --> 00:03:39,687
I'm not gonna remember
your birthday, or
National Assistants' Day.

56
00:03:39,753 --> 00:03:43,491
Not because I don't try
or because I don't want to.
Hold this, please.

57
00:03:43,557 --> 00:03:45,192
I just won't.

58
00:03:45,259 --> 00:03:46,960
And I'm gonna constantly
be after you to stay late
and come early,

59
00:03:47,027 --> 00:03:49,129
even if I can't
pay you on time.

60
00:03:49,196 --> 00:03:51,765
You are trying to talk me
into this job, right?

61
00:03:51,832 --> 00:03:53,467
Yes. But I want to be clear.

62
00:03:53,534 --> 00:03:56,337
200,000 women a year
are diagnosed
with breast cancer.

63
00:03:56,404 --> 00:04:00,073
Getting HER-2 to work could
save a lot of those lives.

64
00:04:00,140 --> 00:04:01,775
200,000 a year?

65
00:04:07,281 --> 00:04:08,882
Oh!
Grams is here!

66
00:04:10,751 --> 00:04:12,353
Good morning, Samuel.

67
00:04:12,420 --> 00:04:14,121
You're going to
sleep in my room.

68
00:04:14,187 --> 00:04:17,658
Well. It's a very small
bed for two people.

69
00:04:17,725 --> 00:04:20,294
I'm going to sleep
with my mom.

70
00:04:20,361 --> 00:04:23,764
Hi, Mom.
Thank you so much
for coming.

71
00:04:23,831 --> 00:04:25,499
Of course, dear.

72
00:04:25,566 --> 00:04:30,304
Although, why Charlie
chose to go on the road
this particular week,

73
00:04:30,371 --> 00:04:34,342
and why you wouldn't come
and stay at my house
remains a mystery.

74
00:04:34,408 --> 00:04:36,377
You do still have
a room there, you know?

75
00:04:36,444 --> 00:04:38,346
I want to be home.
So does Sam.

76
00:04:38,412 --> 00:04:40,280
Could we not go
over this again?

77
00:04:40,348 --> 00:04:42,350
I was merely
pointing out that

78
00:04:42,416 --> 00:04:44,985
it would be
less stressful
for all of us,

79
00:04:45,052 --> 00:04:47,921
you, especially,
to be in a house

80
00:04:47,988 --> 00:04:51,191
that has adequate
space and amenities,

81
00:04:52,426 --> 00:04:54,395
like air conditioning.

82
00:04:58,198 --> 00:04:59,800
This will be fine.

83
00:04:59,867 --> 00:05:01,502
I'll just put
my things away.

84
00:05:01,569 --> 00:05:05,906
And you, young man,
should do the same with
that bicycle of yours.

85
00:05:10,378 --> 00:05:12,413
Why does she have
to be here?

86
00:05:13,781 --> 00:05:17,351
Because she's my mother
and your grandmother.

87
00:05:17,418 --> 00:05:20,320
And next to you and Daddy,
she's all I've got.

88
00:05:23,457 --> 00:05:26,627
Oh, Kate, I love that
you put that up there.

89
00:05:26,694 --> 00:05:28,161
KATE: It's official.
Oh!

90
00:05:28,228 --> 00:05:30,163
Your own shop
on Melrose Avenue.

91
00:05:31,599 --> 00:05:34,368
I can't believe it.
I'm a real designer.

92
00:05:34,435 --> 00:05:36,970
You've been a designer.
The only difference is that

93
00:05:37,037 --> 00:05:39,707
now you're a designer
with overhead.

94
00:05:41,274 --> 00:05:45,312
Oh! Chartreuse,
what was I thinking?

95
00:05:45,379 --> 00:05:46,747
Kate, if nobody
buys anything...

96
00:05:46,814 --> 00:05:48,382
That's not gonna happen.

97
00:05:48,449 --> 00:05:50,317
So, get over here
and make a toast.

98
00:05:50,384 --> 00:05:51,785
We got to
commemorate the day.

99
00:05:51,852 --> 00:05:53,987
You don't miss a beat.
Champagne?

100
00:05:54,054 --> 00:05:55,689
Mmm-hmm.
A good year, too.

101
00:05:55,756 --> 00:05:58,058
What are we going to
toast to? Let's see...

102
00:05:58,125 --> 00:06:00,127
Mmm. I got it.

103
00:06:00,193 --> 00:06:01,429
To good friends...

104
00:06:01,495 --> 00:06:02,563
Yes.

105
00:06:02,630 --> 00:06:04,197
...hard work

106
00:06:04,264 --> 00:06:06,299
and to kicking
some retail ass.

107
00:06:06,366 --> 00:06:07,835
Amen, sister.

108
00:06:08,769 --> 00:06:10,303
Mmm.

109
00:06:10,370 --> 00:06:12,840
It's official.
You make the best cup
of coffee in the world.

110
00:06:12,906 --> 00:06:15,175
Yeah. You say
that every day.

111
00:06:15,242 --> 00:06:17,711
I mean it every day.

112
00:06:17,778 --> 00:06:19,279
You decided
about summer school?

113
00:06:19,346 --> 00:06:21,449
Someone else
can teach it.

114
00:06:21,515 --> 00:06:26,153
I'm going to spend
the summer sleeping in
and getting fat.

115
00:06:26,219 --> 00:06:29,523
And cleaning out
the sun room
for my studio.

116
00:06:29,590 --> 00:06:34,194
Finally. With your talent
you should be making art
instead of teaching it.

117
00:06:50,511 --> 00:06:52,813
Lilly. What are you
doing here?

118
00:06:52,880 --> 00:06:55,115
I need an excuse
to say hello?

119
00:06:56,416 --> 00:06:59,052
This is your lab?
This little room?

120
00:06:59,119 --> 00:07:00,954
I know. The janitor's
closet's bigger.

121
00:07:01,021 --> 00:07:03,624
But the chances
of him curing cancer
are slim to none,

122
00:07:03,691 --> 00:07:05,859
so I got him there.

123
00:07:05,926 --> 00:07:09,597
Lilly Tartikoff, old friend,
Jamie MacGraw, new assistant.

124
00:07:09,663 --> 00:07:11,465
Hi.
Hello.

125
00:07:11,532 --> 00:07:13,467
How's Brandon?
Is he okay?

126
00:07:13,534 --> 00:07:16,269
A star, who shall remain
nameless, is giving him
indigestion,

127
00:07:16,336 --> 00:07:17,871
and the Dodgers
are in a slump.

128
00:07:17,938 --> 00:07:20,007
But other than that,
he's fine.

129
00:07:20,073 --> 00:07:21,642
How's Donna?
I owe her a call.

130
00:07:21,709 --> 00:07:24,778
She's good.
When you call her,
say hi for me.

131
00:07:24,845 --> 00:07:26,614
Poor Donna.

132
00:07:26,680 --> 00:07:28,115
At least I can tell
my husband
he has to come home.

133
00:07:28,181 --> 00:07:30,150
It's not like
he's curing cancer.

134
00:07:30,217 --> 00:07:32,620
Here, don't say
I never gave you anything.

135
00:07:32,686 --> 00:07:34,555
That is every episode
of Hill Street Blues,

136
00:07:34,622 --> 00:07:36,890
which you always miss
because you're always here.

137
00:07:36,957 --> 00:07:38,992
You've got to
be kidding me.

138
00:07:39,059 --> 00:07:41,595
Being married
to the president of NBC
Entertainment has its perks.

139
00:07:41,662 --> 00:07:44,397
You didn't have
to do this.
Thank you so much.

140
00:07:44,464 --> 00:07:47,200
You saved my husband's life.
Thank you.

141
00:07:48,769 --> 00:07:52,005
I'm sorry,
but I promised Donna
I would get him out on time,

142
00:07:52,072 --> 00:07:53,907
and we still have
our rounds.

143
00:07:53,974 --> 00:07:55,976
Good for you.
Keep on him.

144
00:07:56,043 --> 00:08:00,047
And you, lives
need to be saved.
Get back to work.

145
00:08:00,113 --> 00:08:01,114
Bye.
JAMIE: Bye.

146
00:08:01,181 --> 00:08:03,116
Bye, Lilly. Thank you.

147
00:08:03,183 --> 00:08:05,653
All right. You heard her,
let's get back to work.

148
00:08:54,367 --> 00:08:57,304
I'm sorry. I was trying
not to wake you.

149
00:08:57,370 --> 00:08:59,372
Oh, that was thoughtful.

150
00:08:59,439 --> 00:09:01,642
But I couldn't sleep
after you promised to be
home five hours ago

151
00:09:01,709 --> 00:09:02,843
and never showed up.

152
00:09:02,910 --> 00:09:04,344
The specimen
refrigerator
broke and...

153
00:09:04,411 --> 00:09:06,113
I am so not done.

154
00:09:06,179 --> 00:09:07,380
I'm sorry.

155
00:09:07,447 --> 00:09:10,017
An hour-long recital.

156
00:09:10,083 --> 00:09:13,320
I reminded you today,
yesterday. I even put
Jamie on the case.

157
00:09:13,386 --> 00:09:15,355
I did everything but
drive you there myself.

158
00:09:15,422 --> 00:09:16,523
I had to do the
transfer myself.

159
00:09:16,590 --> 00:09:17,891
Your daughter was
expecting you.

160
00:09:17,958 --> 00:09:19,159
There was no one
I could call.

161
00:09:19,226 --> 00:09:20,628
It's my work.
If anything happened,

162
00:09:20,694 --> 00:09:23,196
I'd have to start
all over.
Start all over. I know.

163
00:09:23,263 --> 00:09:26,233
I knew when I married
you what I was in for.

164
00:09:27,434 --> 00:09:30,037
But they just want
their daddy there.

165
00:09:31,371 --> 00:09:34,307
Not every time.
But sometimes.

166
00:09:34,374 --> 00:09:36,476
I'll make it up
to her on Sunday.

167
00:09:36,543 --> 00:09:38,211
That would be good.

168
00:09:42,883 --> 00:09:45,085
Okay. I'm officially
over it.

169
00:09:45,819 --> 00:09:47,554
You're sure?

170
00:09:47,621 --> 00:09:48,922
Yeah.

171
00:09:48,989 --> 00:09:50,891
Because you know
I'm going to kiss you now.

172
00:09:57,364 --> 00:09:58,498
Mmm.

173
00:10:00,100 --> 00:10:01,568
You smell good.

174
00:10:01,635 --> 00:10:04,872
Oh, you, wow,
not so good.

175
00:10:07,607 --> 00:10:10,878
So, how was she?

176
00:10:10,944 --> 00:10:15,382
Honestly, she was the
best sunflower I think
I've ever seen.

177
00:10:15,448 --> 00:10:16,950
You know why?
She gets that from you.

178
00:10:21,088 --> 00:10:23,090
You weren't really
waiting up for me,
were you?

179
00:10:23,156 --> 00:10:25,058
No, I fell asleep reading.

180
00:10:25,125 --> 00:10:27,227
And no offense,
but I really
want to get back.

181
00:10:27,294 --> 00:10:29,763
Then you won't mind
if I go for a run?

182
00:10:29,830 --> 00:10:32,165
'Cause I'm not
gonna have time
in the morning.

183
00:10:32,232 --> 00:10:34,401
Yeah. That's not
gonna happen.

184
00:10:34,467 --> 00:10:36,403
So not happening?
Uh-uh!

185
00:10:36,469 --> 00:10:39,740
Okay. I didn't want
to run anyway.

186
00:10:43,911 --> 00:10:45,578
You've done that
a thousand times.

187
00:10:45,645 --> 00:10:47,247
Well, that's what
science is.

188
00:10:47,314 --> 00:10:48,816
JAMIE: But what exactly
are you doing?

189
00:10:48,882 --> 00:10:50,250
I showed you the plan.

190
00:10:50,317 --> 00:10:52,886
Uh, no. You didn't.

191
00:10:52,953 --> 00:10:55,455
That's the plan.
Step one is discovery.

192
00:10:55,522 --> 00:10:57,057
That's a
one-in-a-million shot

193
00:10:57,124 --> 00:11:00,027
linking the HER-2 protein
with cell growth
in breast tissue.

194
00:11:00,093 --> 00:11:01,895
I did that right
here in this lab.

195
00:11:01,962 --> 00:11:04,497
Step two is to create
a drug from HER-2.

196
00:11:04,564 --> 00:11:05,632
That's where
we are right now.

197
00:11:05,699 --> 00:11:06,934
I'm doing some of
that work right here.

198
00:11:07,000 --> 00:11:08,601
And they're doing
the rest up at Genentech.

199
00:11:08,668 --> 00:11:10,170
And that's a drug company.
Right.

200
00:11:10,237 --> 00:11:12,205
It's a biotech company
up in the Bay Area.

201
00:11:12,272 --> 00:11:13,540
And biotech is...

202
00:11:13,606 --> 00:11:16,777
Is looking for medicines
based on molecular biology.

203
00:11:16,844 --> 00:11:19,079
Step three is
the Mouse Protein Experiment.

204
00:11:19,146 --> 00:11:21,982
I'll explain more
about that when we get
a little bit closer.

205
00:11:22,049 --> 00:11:25,618
Steps four, five and six
are the FDA
clinical drug trials,

206
00:11:25,685 --> 00:11:28,021
to see if the drug works
and how well it works.

207
00:11:28,088 --> 00:11:29,757
Which would lead
us to Step seven,

208
00:11:29,823 --> 00:11:31,859
the Holy Grail,
our drug is approved.

209
00:11:42,335 --> 00:11:44,704
DENNY: Hey, Blake. Blake.

210
00:11:44,772 --> 00:11:46,339
You're not going to
believe this new data.

211
00:11:46,406 --> 00:11:48,575
I was trying to catch you
before you got on the plane.

212
00:11:48,641 --> 00:11:50,043
I've got some bad news.

213
00:11:50,110 --> 00:11:51,812
Okay. How much
are they cutting
our budget this time?

214
00:11:51,879 --> 00:11:53,213
I'm sorry, Denny.

215
00:11:53,280 --> 00:11:55,415
The board has decided
not to continue with HER-2.

216
00:11:55,482 --> 00:11:56,649
You did not
just say that.

217
00:11:56,716 --> 00:11:59,419
They think cancer research
just carries too much risk.

218
00:11:59,486 --> 00:12:01,321
What? They're just
deciding that now?

219
00:12:01,388 --> 00:12:02,990
We spent six years
on this!

220
00:12:03,056 --> 00:12:05,158
Yeah. And they've been
dragging their feet
every step of the way.

221
00:12:05,225 --> 00:12:08,528
We're getting close.
You know we are.
The board knows it, too.

222
00:12:08,595 --> 00:12:10,663
Try to see
their perspective.

223
00:12:10,730 --> 00:12:12,833
Continuing will cost
millions of dollars and
the drug might not work.

224
00:12:12,900 --> 00:12:14,301
But it might!

225
00:12:14,367 --> 00:12:15,535
Take a look
at the new data.

226
00:12:15,602 --> 00:12:17,404
I'm a believer
based on the old data.

227
00:12:17,470 --> 00:12:19,406
It's a hard pill, Denny,
but you got to swallow.

228
00:12:19,472 --> 00:12:21,008
We can't stop.

229
00:12:21,074 --> 00:12:22,609
Not until we know
what we have.

230
00:12:43,897 --> 00:12:46,333
Dinner's ready.
I need to finish.

231
00:12:47,100 --> 00:12:48,201
What's going on?

232
00:12:48,268 --> 00:12:50,003
You haven't said
two words all day.

233
00:12:50,070 --> 00:12:52,205
Genentech is
dropping HER-2.

234
00:12:54,274 --> 00:12:55,742
So you'll take it to
another drug company.

235
00:12:55,809 --> 00:12:56,877
I can't.

236
00:12:56,944 --> 00:12:58,145
Genentech owns the rights.

237
00:12:58,211 --> 00:12:59,212
But you developed
the drug.

238
00:12:59,279 --> 00:13:01,148
It doesn't matter, okay?

239
00:13:01,214 --> 00:13:03,783
I did it using
one of their genes,
so it belongs to them.

240
00:13:03,851 --> 00:13:05,819
Honey, you have been
in this position before

241
00:13:05,886 --> 00:13:07,821
and you always
work it out.

242
00:13:07,888 --> 00:13:11,458
Really not in the mood
to be cheered up right now.
Okay?

243
00:13:12,860 --> 00:13:15,896
I don't care.

244
00:13:15,963 --> 00:13:21,368
I don't. It's Sunday,
the one day of
the week that's ours.

245
00:13:21,434 --> 00:13:25,238
And on Sunday,
I don't care about cancer,
HER-2 or Genentech.

246
00:13:25,305 --> 00:13:26,573
Just our family.

247
00:13:26,639 --> 00:13:28,408
That was our deal
from day one.

248
00:13:30,911 --> 00:13:35,515
So, stop feeling
sorry for yourself,

249
00:13:35,582 --> 00:13:39,019
put a smile on
that cute face, and
come in for dinner.

250
00:13:49,096 --> 00:13:50,363
Daddy!

251
00:14:08,015 --> 00:14:11,218
You're just in time for
the 10:00 tune-up special.

252
00:14:11,284 --> 00:14:13,786
Well, if I were staying,
I'd take you up on it.

253
00:14:13,853 --> 00:14:15,923
You should stay.
It's his first birthday.

254
00:14:15,989 --> 00:14:17,891
We can have another cake
at dinner tomorrow.

255
00:14:17,958 --> 00:14:21,428
A yard full of
screaming children
is not my cup of tea.

256
00:14:21,494 --> 00:14:24,864
Come on, it'll be fun.
I hardly get a chance
to see you.

257
00:14:24,932 --> 00:14:27,767
Really? And that's
something you want?

258
00:14:27,834 --> 00:14:29,769
Just as much as you do.

259
00:14:32,072 --> 00:14:35,175
Um, if she's sleeping,
just let her.

260
00:14:35,242 --> 00:14:37,144
Sleeping

261
00:14:37,210 --> 00:14:41,181
She's tired.
Taking care of two boys
is a lot of work, you know.

262
00:14:42,182 --> 00:14:43,716
You mean three.

263
00:14:47,454 --> 00:14:48,621
Yeah.

264
00:14:54,627 --> 00:14:57,264
Your film looks fine.
Lie down, please.

265
00:14:58,198 --> 00:14:59,967
Lift your left arm.

266
00:15:00,033 --> 00:15:03,236
Have you noticed any lumps
or anything unusual
since your last visit?

267
00:15:03,303 --> 00:15:05,305
No.
Right arm.

268
00:15:05,372 --> 00:15:07,340
Are you doing your
weekly self

269
00:15:07,407 --> 00:15:09,409
Like clockwork.
Good.

270
00:15:09,476 --> 00:15:11,979
You're fine.
See you in six months.

271
00:15:17,484 --> 00:15:20,187
Wham, bam, thank you,
ma'am, to you, too.

272
00:15:26,459 --> 00:15:27,494
Whoa, whoa!

273
00:15:27,560 --> 00:15:28,928
I'm sorry.

274
00:15:28,996 --> 00:15:30,663
I've been paging you
and paging you.

275
00:15:30,730 --> 00:15:32,165
You need to jump
on a plane.

276
00:15:32,232 --> 00:15:33,833
Blake called and
he said it's urgent.

277
00:15:33,900 --> 00:15:34,968
Good urgent?
Bad urgent?

278
00:15:35,035 --> 00:15:36,869
He wouldn't say.
But it's gotta be good.

279
00:15:36,936 --> 00:15:38,972
You're right.
I've got the smallest
budget at UCLA,

280
00:15:39,039 --> 00:15:41,074
the smallest lab
and no Genentech money.

281
00:15:41,141 --> 00:15:42,242
How could it be worse?

282
00:15:42,309 --> 00:15:44,077
It's gonna be good.
You're due.

283
00:15:44,144 --> 00:15:45,845
See you soon.

284
00:15:45,912 --> 00:15:47,414
I don't believe it!

285
00:15:47,480 --> 00:15:49,983
How in the world
did you get the board
to change its mind?

286
00:15:50,050 --> 00:15:52,452
Oh, simple.
Just committed
career suicide.

287
00:15:52,519 --> 00:15:54,287
You committed what?

288
00:15:54,354 --> 00:15:57,957
I can devote 20% of my time
to any project I want.

289
00:15:58,658 --> 00:15:59,726
I chose HER-2.

290
00:15:59,792 --> 00:16:02,029
It did not go over
very well, believe me.

291
00:16:02,095 --> 00:16:04,998
And if we screw this up,
I'm pretty sure
I'll be free to leave.

292
00:16:05,065 --> 00:16:07,700
We won't screw it up.

293
00:16:07,767 --> 00:16:10,070
God help me for
believing in you and this.

294
00:16:10,137 --> 00:16:12,372
I'd sleep a lot better
at night if I didn't.

295
00:16:12,439 --> 00:16:15,675
But listen, you're going to
have to take that lead foot
of yours off the gas.

296
00:16:15,742 --> 00:16:17,910
We're going to have
a lot less lab time
and money.

297
00:16:17,977 --> 00:16:19,579
Got it.
I'm serious.

298
00:16:19,646 --> 00:16:22,482
However slow it's going now,
ratchet that down by half.

299
00:16:22,549 --> 00:16:24,784
You know what?
It really doesn't matter.

300
00:16:24,851 --> 00:16:26,219
I mean, we're still
in the game, right?

301
00:16:26,286 --> 00:16:29,889
Which is more than
we could say two days ago.

302
00:16:29,956 --> 00:16:32,659
Realistically, though,
how soon till we get
a bigger budget?

303
00:16:32,725 --> 00:16:34,694
Get out. Get out.

304
00:16:34,761 --> 00:16:36,696
Put the globe back
and get out.

305
00:16:40,733 --> 00:16:43,536
So, did you decide
on the teaching job?

306
00:16:43,603 --> 00:16:47,440
I'm too busy around here.
The paycheck would have
been nice, though.

307
00:16:47,507 --> 00:16:49,476
Come on.
You're a doctor's wife.

308
00:16:49,542 --> 00:16:51,010
A university doctor.

309
00:16:51,078 --> 00:16:53,646
He gets
a teacher's paycheck.
I'm not complaining.

310
00:16:53,713 --> 00:16:57,417
It's just we're going to
have to win the lottery when
it comes time for college.

311
00:16:57,484 --> 00:17:00,453
Well, if you do win and
you need a bad influence,
I know just the stores.

312
00:17:01,921 --> 00:17:03,690
Maybe one spree.

313
00:17:03,756 --> 00:17:06,226
I'd give the rest to
Denny for his research.

314
00:17:06,293 --> 00:17:08,128
No. Let Genentech
pay for that.

315
00:17:08,195 --> 00:17:09,529
I can't count on them.

316
00:17:09,596 --> 00:17:12,765
They're constantly
threatening to cut
his funding.

317
00:17:12,832 --> 00:17:14,201
But he's trying
to cure cancer.

318
00:17:14,267 --> 00:17:15,568
Who wouldn't
support that?

319
00:17:15,635 --> 00:17:18,004
Well, if they get behind
the drug and it fails,

320
00:17:18,071 --> 00:17:21,541
it could bankrupt
the whole company.
They're terrified.

321
00:17:23,110 --> 00:17:24,577
Well, he never said
anything to me.

322
00:17:24,644 --> 00:17:26,079
Oh, you know Denny.

323
00:17:26,146 --> 00:17:28,781
He could break his arm
and you wouldn't know it.

324
00:17:31,518 --> 00:17:33,386
He's really suffering.

325
00:17:38,325 --> 00:17:40,059
Don't say anything.

326
00:17:41,060 --> 00:17:42,329
I won't.

327
00:17:50,103 --> 00:17:51,571
I've made a decision.

328
00:17:51,638 --> 00:17:53,673
I'm going to raise money
for your research.

329
00:17:53,740 --> 00:17:55,175
You're going to what?

330
00:17:55,242 --> 00:17:57,344
Last night
I was sitting in my
Beverly Hills home,

331
00:17:57,410 --> 00:17:59,846
with my wonderful husband
and my beautiful daughter,

332
00:17:59,912 --> 00:18:03,283
and I was suddenly
overwhelmed with how
much I've been given.

333
00:18:03,350 --> 00:18:04,551
I need to start
giving back.

334
00:18:04,617 --> 00:18:07,254
And I'm going to
do it through you.

335
00:18:07,320 --> 00:18:10,623
Very, very generous
of you, Lilly, but
I can't let you do that.

336
00:18:10,690 --> 00:18:12,325
You need the money.

337
00:18:12,392 --> 00:18:14,261
What, you're going to
cure cancer in here?

338
00:18:14,327 --> 00:18:15,928
Lilly, the fact that
you would even think

339
00:18:15,995 --> 00:18:17,364
about doing something
like that for me

340
00:18:17,430 --> 00:18:19,532
means more
than I can say.

341
00:18:19,599 --> 00:18:22,369
But I can't let you do that.
We're friends.

342
00:18:22,435 --> 00:18:24,137
Are you kidding me?

343
00:18:24,204 --> 00:18:27,073
You spent
I don't know how
many days and nights

344
00:18:27,140 --> 00:18:29,642
away from Donna
and the kids
with Brandon's chemo

345
00:18:29,709 --> 00:18:32,078
and helping me
get through it.

346
00:18:32,145 --> 00:18:33,946
You saved him.

347
00:18:34,013 --> 00:18:35,315
That makes us more
than friends, Denny.
We're family.

348
00:18:35,382 --> 00:18:38,285
Yes. Which is why
I can't take your money.

349
00:18:38,351 --> 00:18:40,420
It's not going
to be my money.
I'm going to raise it.

350
00:18:40,487 --> 00:18:41,554
No.

351
00:18:41,621 --> 00:18:43,556
No?

352
00:18:43,623 --> 00:18:46,726
Look, Mr. "I Don't Care
if I Work in the Smallest
Lab in the Universe,"

353
00:18:46,793 --> 00:18:49,629
I'm offering you money
for your research.

354
00:18:50,430 --> 00:18:51,664
Now, if you don't want it,

355
00:18:51,731 --> 00:18:54,000
I'll go find some other
deserving doctor who does.

356
00:18:54,066 --> 00:18:57,837
Great. Now can we be done
with this conversation?

357
00:19:00,106 --> 00:19:02,842
You absolutely stink
at accepting gifts.

358
00:19:03,676 --> 00:19:04,811
Get over it!

359
00:19:04,877 --> 00:19:06,579
You're this close
to losing HER-2

360
00:19:06,646 --> 00:19:09,081
because some executives
are running scared.

361
00:19:09,148 --> 00:19:13,052
Well, screw them.
The cavalry is here.

362
00:19:13,119 --> 00:19:15,888
And you are going to
have your own money.

363
00:19:18,858 --> 00:19:20,427
It's a promise.

364
00:19:21,861 --> 00:19:23,129
Goodbye.

365
00:19:38,645 --> 00:19:41,914
Oh, Brandon,
good to see you.

366
00:19:46,185 --> 00:19:47,254
Hi.

367
00:19:53,293 --> 00:19:55,061
Thank you very much.

368
00:19:58,465 --> 00:20:00,099
Wow, Brandon
knows everyone.

369
00:20:00,166 --> 00:20:02,502
Yes, and if he doesn't,
they know him.

370
00:20:02,569 --> 00:20:06,005
But don't worry.
He'll be here
before the appetizers.

371
00:20:09,676 --> 00:20:10,877
Is that an actor?

372
00:20:10,943 --> 00:20:13,413
No. Better.
That's Ron Perelman.

373
00:20:13,480 --> 00:20:14,547
Who?
Who?

374
00:20:14,614 --> 00:20:16,516
He's one of the
richest men in America.

375
00:20:16,583 --> 00:20:18,285
He owns Revlon.

376
00:20:19,652 --> 00:20:22,722
I'll be back in two minutes.
Hopefully five.

377
00:20:25,825 --> 00:20:27,093
Ron Perelman?

378
00:20:27,159 --> 00:20:28,328
Yes?

379
00:20:28,395 --> 00:20:31,197
We haven't officially met.
I'm Lilly Tartikoff.

380
00:20:31,264 --> 00:20:34,534
So you're Lilly.
Is Brandon with you?

381
00:20:34,601 --> 00:20:37,169
Almost. He's making
his way to the table.

382
00:20:37,236 --> 00:20:39,439
I thought I would take
a minute to say hello.

383
00:20:39,506 --> 00:20:40,907
Well, I'm glad you did.

384
00:20:40,973 --> 00:20:43,142
These are my friends,
Peter and Bindy Hawn.

385
00:20:43,209 --> 00:20:45,177
Lilly is on our
Products Advisory Board

386
00:20:45,244 --> 00:20:47,980
and for the past two
years has been
sending me suggestions

387
00:20:48,047 --> 00:20:49,215
for our ad campaign.

388
00:20:49,282 --> 00:20:51,784
I used to be on that board.
But I don't recall

389
00:20:51,851 --> 00:20:53,653
anyone ever sending
in a suggestion.

390
00:20:53,720 --> 00:20:56,289
No one did.
Until Lilly.

391
00:20:57,524 --> 00:21:01,093
Ask for my opinion,
you're going to get it.

392
00:21:01,160 --> 00:21:02,695
I don't want
to take your time.

393
00:21:02,762 --> 00:21:04,764
I wanted to ask a favor.

394
00:21:04,831 --> 00:21:06,132
Of course.

395
00:21:06,198 --> 00:21:08,267
Do you see the man
at that table there?

396
00:21:09,235 --> 00:21:11,003
That's Dr. Dennis Slamon.

397
00:21:11,070 --> 00:21:14,507
He's on the verge of
discovering something
very important.

398
00:21:14,574 --> 00:21:16,476
It's a new kind of
drug for breast cancer.

399
00:21:16,543 --> 00:21:18,411
And he needs money.

400
00:21:21,381 --> 00:21:22,949
I'm sure he does,

401
00:21:23,015 --> 00:21:26,319
but this is neither the time
nor the place to discuss it.

402
00:21:26,386 --> 00:21:29,656
All I want
is a chance to tell
you about his work.

403
00:21:32,425 --> 00:21:36,496
Call my office.
We'll discuss it
over lunch.

404
00:21:36,563 --> 00:21:39,699
HER-2 is a growth gene
that controls the...

405
00:21:41,801 --> 00:21:42,935
The...

406
00:21:43,002 --> 00:21:44,737
Growth of cells.

407
00:21:44,804 --> 00:21:46,238
Give me that.
Give it to me.

408
00:21:46,305 --> 00:21:47,807
You don't need that.

409
00:21:47,874 --> 00:21:51,678
Have you been here
the last two hours?
I'm not a memorizer.

410
00:21:51,744 --> 00:21:53,179
Well, I don't want
you to memorize it.

411
00:21:53,245 --> 00:21:55,114
I want you to
understand the concept.

412
00:21:55,181 --> 00:21:57,584
Lilly, just be
conversational.

413
00:21:57,650 --> 00:21:59,652
No one is more
conversational than I am.

414
00:21:59,719 --> 00:22:01,921
But this is
the Revlon Foundation Board.

415
00:22:01,988 --> 00:22:04,557
I get one shot
to get you more money.

416
00:22:04,624 --> 00:22:06,393
I have to know
what I'm saying.

417
00:22:06,459 --> 00:22:08,395
What you're saying
is very simple.

418
00:22:08,461 --> 00:22:10,763
HER-2 is a gene
that controls
the growth of cells

419
00:22:10,830 --> 00:22:12,865
in the breast tissue
of a third of all women.

420
00:22:12,932 --> 00:22:15,735
And when those women
get breast cancer, it's
a very aggressive form.

421
00:22:15,802 --> 00:22:19,238
And there's no
treatment available,
not even chemo.

422
00:22:19,305 --> 00:22:21,374
So most of them
will die.

423
00:22:21,441 --> 00:22:22,775
But if my drug
is successful,

424
00:22:22,842 --> 00:22:25,077
it's going to offer
hope to these women
for the first time,

425
00:22:25,144 --> 00:22:26,813
saving 40,000 lives a year.

426
00:22:26,879 --> 00:22:29,449
That's enough to
fill the Rose Bowl
every other year.

427
00:22:30,683 --> 00:22:34,120
Maybe if we gave you
some lipstick and a wig...

428
00:22:34,186 --> 00:22:37,724
Lilly, you'll be fine.
Just tell them that I'm at
a make-it-or-break-it point.

429
00:22:37,790 --> 00:22:39,859
If I had more money,
I could do the work
more quickly.

430
00:22:39,926 --> 00:22:41,961
And if the drug works,
and I think it will,

431
00:22:42,028 --> 00:22:44,864
we can get it approved
and on the market
five to six years faster.

432
00:22:44,931 --> 00:22:49,368
Six years times 40,000
is a quarter million
lives potentially saved.

433
00:22:50,102 --> 00:22:51,504
By Revlon.

434
00:22:52,439 --> 00:22:53,573
Okay?

435
00:22:54,907 --> 00:22:58,177
Okay. Once more,
from the top.

436
00:23:07,487 --> 00:23:09,422
Andy, just the man
I wanted to see.

437
00:23:09,489 --> 00:23:11,023
Denny, you know
I'm a believer in HER-2

438
00:23:11,090 --> 00:23:12,559
and one of your
biggest supporters.

439
00:23:12,625 --> 00:23:13,860
But the answer is no.

440
00:23:13,926 --> 00:23:15,361
I haven't asked
you anything yet.

441
00:23:15,428 --> 00:23:17,830
Have you ever asked me
for anything besides
more money?

442
00:23:17,897 --> 00:23:19,231
Last week I asked
you about your dog.

443
00:23:19,298 --> 00:23:21,233
Right before you hit me
up for more equipment.

444
00:23:21,300 --> 00:23:22,368
Which I still need,
by the way.

445
00:23:22,435 --> 00:23:23,536
CARL: And which
you're not going to get.

446
00:23:23,603 --> 00:23:25,672
That's not your call,
Reinhart.

447
00:23:25,738 --> 00:23:28,508
No. But I was in the meeting
and half the board members
agree with me.

448
00:23:28,575 --> 00:23:30,910
An antibody approach
to cancer is never
going to work,

449
00:23:30,977 --> 00:23:34,313
which makes HER-2
a terrific waste
of time and money.

450
00:23:34,380 --> 00:23:35,915
So half of them
agree with me?

451
00:23:35,982 --> 00:23:39,786
Wow. You see,
I thought it was
way less than that.

452
00:23:39,852 --> 00:23:42,354
Thanks for the
encouragement, Carl.

453
00:23:44,156 --> 00:23:46,659
We're late.
I promise next time
we'll talk, okay?

454
00:23:46,726 --> 00:23:49,261
I'll be back on Thursday.

455
00:23:49,328 --> 00:23:52,899
You're going to be glad
you kept this going.
You'll see.

456
00:23:55,668 --> 00:23:57,036
You'll see.

457
00:23:58,104 --> 00:23:59,972
Matt spilled his
cereal on Daddy.

458
00:24:00,039 --> 00:24:01,708
I did not.

459
00:24:01,774 --> 00:24:04,076
How many times
have I told you not
to play at the table?

460
00:24:04,143 --> 00:24:05,211
JOEY LYN: A hundred.

461
00:24:05,277 --> 00:24:06,445
Nuh-uh...

462
00:24:06,513 --> 00:24:09,248
Could we please not fight?
Two hundred.

463
00:24:11,250 --> 00:24:13,185
That was Lilly.

464
00:24:13,252 --> 00:24:16,489
She just finished
the meeting at Revlon.

465
00:24:18,725 --> 00:24:20,126
She did it.

466
00:24:20,192 --> 00:24:23,596
You mean
Ron Perelman said yes?

467
00:24:23,663 --> 00:24:27,133
Yeah.
Honey, that's great!

468
00:24:27,199 --> 00:24:29,301
How much
is he gonna give you?

469
00:24:29,368 --> 00:24:31,303
$50,000

470
00:24:31,738 --> 00:24:32,872
Um...

471
00:24:33,573 --> 00:24:36,743
No. $2.4 million.

472
00:24:36,809 --> 00:24:40,479
It's the biggest amount
ever given to a researcher
without restrictions.

473
00:24:40,547 --> 00:24:44,250
Oh, my God!
Oh, my God!

474
00:24:46,653 --> 00:24:48,655
Wait. You're sure?

475
00:24:48,721 --> 00:24:50,356
They're just
giving it to you?

476
00:24:50,422 --> 00:24:52,024
There are no
strings attached?

477
00:24:52,091 --> 00:24:56,696
Um, Lilly has to throw
a fundraiser every year
to make more.

478
00:24:57,930 --> 00:25:00,266
More money?
More money.

479
00:25:00,332 --> 00:25:01,433
Oh!

480
00:25:03,302 --> 00:25:06,706
Nicole, sweetheart.
It's me. Mom.

481
00:25:06,773 --> 00:25:08,340
Where's Charlie?

482
00:25:08,407 --> 00:25:11,410
He's downstairs
taking care
of the paperwork.

483
00:25:11,477 --> 00:25:14,080
The biopsy was malignant.

484
00:25:14,146 --> 00:25:17,784
I know. I know, sweetheart.
But you're going to be fine.

485
00:25:17,850 --> 00:25:19,652
Mom.

486
00:25:19,719 --> 00:25:21,921
You just sleep now,
sweetheart.

487
00:25:21,988 --> 00:25:25,758
And when you wake up,
we'll get good news.

488
00:25:26,759 --> 00:25:28,227
Mom.

489
00:25:30,162 --> 00:25:34,934
Don't worry. I'll be
right here waiting
for you. Charlie, too.

490
00:25:39,672 --> 00:25:42,775
Lie down, please.
Lift your left arm.

491
00:25:46,012 --> 00:25:47,814
Hello to you, too.

492
00:25:47,880 --> 00:25:49,281
Sit up, please.

493
00:25:52,351 --> 00:25:56,388
The film shows
a fast-growing mass
in your left breast.

494
00:25:56,455 --> 00:25:59,391
From the looks of it,
it's cancer.

495
00:25:59,458 --> 00:26:01,193
But I was just here
six months ago.

496
00:26:01,260 --> 00:26:04,263
As I said,
it's fast-growing.

497
00:26:04,330 --> 00:26:07,399
How old was your mother
when she was diagnosed?

498
00:26:08,635 --> 00:26:10,302
30.
And you are?

499
00:26:11,704 --> 00:26:12,772
30.

500
00:26:14,240 --> 00:26:17,309
I'm referring you to
an oncologist, Dr. Banks.

501
00:26:18,878 --> 00:26:22,181
Well, if it is cancer,
what are my options?

502
00:26:22,248 --> 00:26:27,586
Mastectomy, radiation,
chemotherapy, whatever
Dr. Banks prescribes.

503
00:26:27,654 --> 00:26:32,058
But that's what they
gave my mom 15 years ago
and she died.

504
00:26:32,124 --> 00:26:34,093
They don't work
for everyone.

505
00:26:34,160 --> 00:26:36,729
But they're still
the standard of care.

506
00:26:36,796 --> 00:26:39,065
There's got to be
something else.

507
00:26:39,131 --> 00:26:41,600
Not yet. Good luck.

508
00:27:12,832 --> 00:27:14,633
Honey, come in here.

509
00:27:19,038 --> 00:27:20,639
What's up, baby?

510
00:27:21,908 --> 00:27:24,343
I found a lump
in my breast.

511
00:27:25,778 --> 00:27:27,246
Are you sure?

512
00:27:28,681 --> 00:27:30,382
Yes, it's cancer.

513
00:27:30,449 --> 00:27:31,751
You don't know that.

514
00:27:33,385 --> 00:27:34,721
Yes, I do.

515
00:27:48,801 --> 00:27:50,302
WOMAN: Lilly, Lilly.

516
00:27:56,709 --> 00:27:58,077
This is surreal.

517
00:27:58,144 --> 00:28:00,279
I passed surreal
a long time ago.

518
00:28:00,346 --> 00:28:02,114
Good to see you both.

519
00:28:02,181 --> 00:28:03,515
Thank you for this.

520
00:28:03,582 --> 00:28:05,484
Tonight is just
the beginning.

521
00:28:15,627 --> 00:28:16,796
Hi.

522
00:28:16,863 --> 00:28:18,197
Hi.
Hi.

523
00:28:18,264 --> 00:28:20,900
Can you believe it?
Everybody came.

524
00:28:20,967 --> 00:28:24,103
I've been sick to my stomach
for five months worrying
that they wouldn't.

525
00:28:24,170 --> 00:28:25,637
You look beautiful.

526
00:28:25,704 --> 00:28:27,139
You both look
like movie stars.

527
00:28:27,206 --> 00:28:28,474
Thank you.

528
00:28:28,540 --> 00:28:30,142
Okay. I've got
to work the room.

529
00:28:30,209 --> 00:28:31,310
I will see you
at the table.

530
00:28:31,377 --> 00:28:32,678
Great.
Okay.

531
00:28:32,745 --> 00:28:36,849
Oh! And tonight is
making us $400,000 more,

532
00:28:36,916 --> 00:28:38,684
so that ought to keep you
in test tubes a bit longer.

533
00:28:38,751 --> 00:28:39,919
And get you a bigger lab.

534
00:28:39,986 --> 00:28:41,087
Wow!

535
00:28:42,688 --> 00:28:44,356
I'll see you. Hi.

536
00:28:49,561 --> 00:28:53,399
I just got to say,
I'm really stoked
to be working here.

537
00:28:53,465 --> 00:28:54,733
That's great.

538
00:28:54,801 --> 00:28:56,235
When does
the HER

539
00:28:56,302 --> 00:28:57,870
After we do the
Mouse Protein Test,

540
00:28:57,937 --> 00:29:00,472
which we're waiting
for Genentech to approve.

541
00:29:00,539 --> 00:29:02,241
Mouse protein?

542
00:29:02,308 --> 00:29:04,510
HER-2 is a protein
and they grow it in mice

543
00:29:04,576 --> 00:29:06,412
because it's illegal
to grow in humans.

544
00:29:06,478 --> 00:29:08,881
And mouse protein
is the most
like human tissue.

545
00:29:08,948 --> 00:29:13,352
So it adds another step,
because they have to test
to make sure it's safe.

546
00:29:13,419 --> 00:29:14,987
What if Genentech says
you can't test it?

547
00:29:15,054 --> 00:29:17,957
They won't.
I'll be back at 2:00.

548
00:29:20,259 --> 00:29:24,463
Don't mind him.
We've just been waiting
to hear for six months.

549
00:29:25,664 --> 00:29:28,667
If they say no,
then it's over.

550
00:29:33,505 --> 00:29:36,208
Could you
go next door and get
the boys, please?

551
00:29:36,275 --> 00:29:39,178
I was hoping we could
have a cup of tea.

552
00:29:39,245 --> 00:29:43,349
Maybe in the backyard.
It's such a beautiful day.
Not too hot, not too cold.

553
00:29:43,415 --> 00:29:44,550
Hmm?

554
00:29:45,751 --> 00:29:47,019
Okay. That would be nice.

555
00:29:47,086 --> 00:29:49,621
Excellent. You sit down.
I'll get it.

556
00:29:57,029 --> 00:29:58,831
I'm sorry.

557
00:29:58,898 --> 00:30:00,399
Don't be silly.

558
00:30:00,466 --> 00:30:03,469
How hard is it to
make a pot of tea?

559
00:30:03,535 --> 00:30:06,305
That you're gonna
lose someone again.

560
00:30:06,372 --> 00:30:08,174
I am not losing you.

561
00:30:10,409 --> 00:30:12,678
I think it would be
easier for everyone

562
00:30:12,744 --> 00:30:16,849
if we just accept it
and enjoy the time
we have left.

563
00:30:16,916 --> 00:30:18,750
Oh, yes,
by all means.

564
00:30:18,817 --> 00:30:20,786
Let's take
the easy way out.

565
00:30:20,853 --> 00:30:22,922
It's just your life
we're talking about.

566
00:30:24,123 --> 00:30:26,492
Since when did I
raise a quitter?

567
00:30:26,558 --> 00:30:28,760
I have stage-four
cancer, Mom.

568
00:30:30,997 --> 00:30:33,532
We haven't run out
of doctors yet.

569
00:30:39,638 --> 00:30:41,908
No, we haven't.

570
00:30:43,542 --> 00:30:46,979
Just tell me we're
beyond the "K's," right?

571
00:30:47,046 --> 00:30:49,715
Oh! We're well
into the "M's."

572
00:30:49,781 --> 00:30:51,850
Okay, good.

573
00:30:51,918 --> 00:30:54,286
I'm going to go
change and, uh...

574
00:31:16,008 --> 00:31:17,609
Cream or lemon?

575
00:31:17,676 --> 00:31:19,578
I think it's cream today.

576
00:31:53,545 --> 00:31:57,316
I hate chemo.
I hate chemo.

577
00:31:59,751 --> 00:32:01,787
WOMAN: Your mom's
on line two.

578
00:32:03,089 --> 00:32:04,823
Hey, Mom, what's up?

579
00:32:20,306 --> 00:32:21,974
Hey, what's up?

580
00:32:24,910 --> 00:32:26,912
Um, I've been behind you
and Denny for a long time,

581
00:32:26,979 --> 00:32:29,881
so I'm going to
ask you flat out.

582
00:32:29,948 --> 00:32:32,951
Are we ready to take HER-2
to the next step?

583
00:32:34,153 --> 00:32:35,587
100%.

584
00:32:38,024 --> 00:32:41,893
Okay. I'm approving
the Mouse Protein study.

585
00:32:41,960 --> 00:32:46,598
Call Slamon and give him
the go-ahead. Tell him
he needs to hurry.

586
00:32:46,665 --> 00:32:50,002
Oh, uh, he'll be ready,
Andy. Believe me.

587
00:32:51,137 --> 00:32:53,272
Hey, you okay?

588
00:32:55,741 --> 00:32:58,377
My mother was just
diagnosed
with breast cancer.

589
00:33:01,747 --> 00:33:03,082
I'm sorry.

590
00:33:14,793 --> 00:33:16,728
Did you get Ricky
to sleep?

591
00:33:16,795 --> 00:33:18,030
Mmm-hmm.

592
00:33:19,431 --> 00:33:20,966
Listen to this.

593
00:33:21,033 --> 00:33:24,636
"UCLA is looking
for volunteers with
advanced cancer

594
00:33:24,703 --> 00:33:27,239
"to test
an experimental drug."

595
00:33:27,306 --> 00:33:30,476
It says to call
a Dr. Slamon.

596
00:33:33,645 --> 00:33:35,747
There's no harm
in calling.

597
00:33:37,283 --> 00:33:39,518
You do qualify
for the study.

598
00:33:41,353 --> 00:33:44,590
And I know your time
is very, very precious,

599
00:33:44,656 --> 00:33:47,793
so I want to thank you
for giving a week of it
to me.

600
00:33:47,859 --> 00:33:52,331
I'd be lying if I didn't
tell you I'm hoping for
a miracle.

601
00:33:52,398 --> 00:33:56,102
Hope is a good thing.
I do it all the time.

602
00:33:56,168 --> 00:33:58,637
I want you to remember
that this is only a test

603
00:33:58,704 --> 00:34:02,441
to see if the drug that
was grown in mice can be
tolerated by people.

604
00:34:02,508 --> 00:34:04,710
Now, that means
I can only give you
one dose.

605
00:34:04,776 --> 00:34:06,812
But if it works
like I think it will,

606
00:34:06,878 --> 00:34:08,880
it might give you
a little bit more time.

607
00:34:08,947 --> 00:34:12,284
And we're talking about
the time you have left.

608
00:34:12,351 --> 00:34:16,988
So I want you to
take a day or two
and think about it.

609
00:34:17,055 --> 00:34:20,759
And whatever you decide,
is the right decision. Okay?

610
00:34:22,161 --> 00:34:24,496
I don't need to
think about it.

611
00:34:30,269 --> 00:34:32,504
Good morning, everyone.

612
00:34:32,571 --> 00:34:35,407
Today is a historic day.

613
00:34:35,474 --> 00:34:38,544
We're here to do
something that has
never been done before.

614
00:34:38,610 --> 00:34:42,448
To inject a drug that
was grown in mouse
protein into people

615
00:34:42,514 --> 00:34:44,350
to see if it's safe.

616
00:34:44,416 --> 00:34:46,618
I have every faith
that it will not
harm you in any way.

617
00:34:46,685 --> 00:34:50,256
And hopefully,
if the drug works
like I think it will,

618
00:34:50,322 --> 00:34:52,858
it'll give you more time.

619
00:34:52,924 --> 00:34:54,193
Good morning, Nicole.

620
00:34:54,260 --> 00:34:55,461
Good morning.

621
00:34:56,162 --> 00:34:57,263
Are you ready?

622
00:34:57,329 --> 00:34:58,430
Yes.

623
00:35:23,555 --> 00:35:27,025
Congratulations.
You just made history.

624
00:35:30,329 --> 00:35:32,498
Good morning.
WOMAN: Good morning.

625
00:35:39,538 --> 00:35:41,807
We've got a reaction.
Nicole Wilson.

626
00:35:59,591 --> 00:36:01,193
DENNY: Miss Mouse Ears.

627
00:36:07,599 --> 00:36:10,135
You just finished
the Mouse Protein Test
four months ago.

628
00:36:10,202 --> 00:36:11,703
In corporate time
that's like five minutes.

629
00:36:11,770 --> 00:36:13,639
Yeah. That's just
long enough for them
to forget about us.

630
00:36:13,705 --> 00:36:16,508
We have to start
the Phase One Trial.
They have to say yes.

631
00:36:16,575 --> 00:36:19,878
Truth? I think most of
them wish they'd never
heard of you or HER-2.

632
00:36:19,945 --> 00:36:22,881
Yeah? Tell me
something I don't know.

633
00:36:22,948 --> 00:36:25,584
Hello.
ANDY: Denny, nice to see you.

634
00:36:25,651 --> 00:36:28,220
Unnecessary. We have
everything we need
to make our decision.

635
00:36:28,287 --> 00:36:31,757
I just want to remind you
of a couple of things first.

636
00:36:34,393 --> 00:36:37,028
HER-2 is the most
promising drug this
company has ever seen.

637
00:36:37,095 --> 00:36:40,866
I stood right here and
I did something that has
never been done before.

638
00:36:40,932 --> 00:36:44,035
I shrank a cancer tumor
with six drops of our drug.

639
00:36:44,102 --> 00:36:47,205
No poison, no chemo.
Just the antibody.

640
00:36:47,273 --> 00:36:50,509
Well, it's a big leap
from shrinking a tumor
in a dish

641
00:36:50,576 --> 00:36:52,744
to curing cancer, Doctor.

642
00:36:52,811 --> 00:36:54,413
This isn't a cure.

643
00:36:54,480 --> 00:36:56,214
It's a treatment to
shrink cancer tumors
and make them inactive.

644
00:36:56,282 --> 00:36:57,949
Which is better than
chemo and radiation

645
00:36:58,016 --> 00:36:59,918
because it has
no side effects.

646
00:36:59,985 --> 00:37:02,721
I wish we could know
without an official study
that the drug will work.

647
00:37:02,788 --> 00:37:05,691
But if we test it
and have a bad result,

648
00:37:05,757 --> 00:37:08,694
it will be the Interferon
disaster all over again.

649
00:37:08,760 --> 00:37:12,163
It's the only cancer
drug we ever developed
and it almost ruined us.

650
00:37:12,230 --> 00:37:13,832
You developed that
based on no hard evidence.

651
00:37:13,899 --> 00:37:15,534
I have shown you real data.

652
00:37:15,601 --> 00:37:17,503
Real data that
HER-2 can work.

653
00:37:17,569 --> 00:37:19,771
We can't base our decision
just on the science.

654
00:37:19,838 --> 00:37:21,973
We have a responsibility
to the company.

655
00:37:22,040 --> 00:37:23,875
And spending millions
on HER-2

656
00:37:23,942 --> 00:37:26,745
means we aren't
spending it on more
promising drugs.

657
00:37:26,812 --> 00:37:28,046
When you put all
the pieces together,

658
00:37:28,113 --> 00:37:31,683
the potential downside
is just too severe.

659
00:37:31,750 --> 00:37:35,587
Well, clearly,
you don't have anyone
with cancer in your life.

660
00:37:37,122 --> 00:37:41,360
How lucky for you.
Well, I do.

661
00:37:44,095 --> 00:37:46,832
I speak to cancer patients
and their families every day,

662
00:37:46,898 --> 00:37:49,535
and I hope for their sake
that one day there's a better
treatment out there

663
00:37:49,601 --> 00:37:53,238
than the current
slash and burn that
exists at the moment!

664
00:37:57,343 --> 00:38:01,246
When I was a kid,
I watched a doctor
save my father's life

665
00:38:01,313 --> 00:38:03,449
and I knew in that
moment that I wanted
to do what he did

666
00:38:03,515 --> 00:38:05,817
because when you save
someone's life, you're
not just saving them,

667
00:38:05,884 --> 00:38:07,619
you're saving
everyone around them.

668
00:38:07,686 --> 00:38:09,355
And now, when I look
into a woman's eyes

669
00:38:09,421 --> 00:38:11,056
and tell her that
her cancer is terminal

670
00:38:11,122 --> 00:38:13,625
and she tells me,
"What other treatments
are available?"

671
00:38:13,692 --> 00:38:16,227
and I tell her,
"We don't have any,"

672
00:38:17,429 --> 00:38:19,130
I know that we do.

673
00:38:20,131 --> 00:38:22,200
MAN: But you don't know
HER-2 will work.

674
00:38:22,267 --> 00:38:25,504
I do know! I know!

675
00:38:27,205 --> 00:38:28,507
Don't throw
this chance away!

676
00:38:28,574 --> 00:38:31,643
Maybe you've been sitting
behind a desk for too long.

677
00:38:31,710 --> 00:38:34,112
Maybe I've been
on the front lines longer
than I should have,

678
00:38:34,179 --> 00:38:37,115
but for God's sake,
don't forget who we are!

679
00:38:39,184 --> 00:38:41,086
We're not businessmen.

680
00:38:46,358 --> 00:38:47,893
We're doctors.

681
00:38:51,630 --> 00:38:53,765
Approve the
Phase One Trial.

682
00:39:03,241 --> 00:39:04,843
You guys are fast.

683
00:39:04,910 --> 00:39:06,778
We could still
use some help.

684
00:39:06,845 --> 00:39:09,515
I was working on
my masterpiece.

685
00:39:09,581 --> 00:39:10,716
Hmm?

686
00:39:12,418 --> 00:39:14,185
You look beautiful.

687
00:39:14,252 --> 00:39:18,256
Not too bad for someone
who wasn't supposed to
make it till Christmas, huh?

688
00:39:20,859 --> 00:39:23,028
Let's put this
right in the middle.

689
00:39:23,094 --> 00:39:25,063
CHILD: Ooh! Like that.

690
00:39:25,130 --> 00:39:26,465
That's us!

691
00:39:31,069 --> 00:39:32,504
You look so pretty.

692
00:39:51,389 --> 00:39:53,124
What are you doing?

693
00:39:53,759 --> 00:39:55,126
Loving you.

694
00:39:57,829 --> 00:39:59,230
But, Mom,
I've got soccer.

695
00:39:59,297 --> 00:40:01,166
Mother's prerogative.

696
00:40:19,585 --> 00:40:21,352
Ellie?

697
00:40:21,419 --> 00:40:23,154
Hi. Do I know you?

698
00:40:23,989 --> 00:40:25,524
I'm Josh.

699
00:40:26,091 --> 00:40:27,826
Thank you.

700
00:40:27,893 --> 00:40:29,995
Oh, I'm meeting
a friend.

701
00:40:30,061 --> 00:40:31,630
Yeah, me.

702
00:40:33,064 --> 00:40:34,700
Kate set us up.

703
00:40:34,766 --> 00:40:36,367
Oh, gosh.

704
00:40:38,336 --> 00:40:40,706
Look, I'm sorry.
I don't date.

705
00:40:40,772 --> 00:40:42,641
You do eat?

706
00:40:44,976 --> 00:40:47,646
Look, Josh...
We're here, so why not?

707
00:40:47,713 --> 00:40:50,649
We'll eat fast.
We don't even
have to talk.

708
00:40:55,521 --> 00:40:56,955
DR. BROWN: The cancer is back.

709
00:40:57,022 --> 00:40:59,290
I'm scheduling another
round of chemotherapy.

710
00:40:59,357 --> 00:41:00,458
No.

711
00:41:02,728 --> 00:41:04,963
No more chemo.
We've decided.

712
00:41:06,364 --> 00:41:08,567
It's a quality
of life issue.

713
00:41:10,101 --> 00:41:13,238
I understand.
I'm very sorry.

714
00:41:15,941 --> 00:41:18,009
There is an outside chance.

715
00:41:18,076 --> 00:41:21,046
A colleague is
going to be testing
an experimental drug.

716
00:41:21,112 --> 00:41:23,314
I'd like to send
your slides.

717
00:41:25,183 --> 00:41:26,484
Whatever.

718
00:41:27,953 --> 00:41:29,821
Hey. I've been
waiting for you.

719
00:41:29,888 --> 00:41:32,891
I got some news.
The board voted yes.

720
00:41:32,958 --> 00:41:34,092
We're moving
to Phase One?

721
00:41:34,159 --> 00:41:35,426
Yeah, but there's trouble.

722
00:41:35,493 --> 00:41:36,762
They put Reinhart
in charge.

723
00:41:36,828 --> 00:41:38,129
Reinhart?

724
00:41:38,196 --> 00:41:41,499
Why? He doesn't even
believe in HER-2.

725
00:41:41,567 --> 00:41:43,401
But you know what,
a go is a go, so...

726
00:41:43,468 --> 00:41:45,136
Let me finish, Denny.

727
00:41:45,203 --> 00:41:48,540
He's bringing in these
so-called "thought leaders"
to head the study.

728
00:41:48,607 --> 00:41:49,841
He's not including you.

729
00:41:49,908 --> 00:41:51,342
But it's my study.

730
00:41:51,409 --> 00:41:54,145
It's Genentech's study
and they put Reinhart
in charge.

731
00:41:54,212 --> 00:41:57,015
I'm sorry.
I went to bat for you,
but it's his call.

732
00:41:57,082 --> 00:41:59,250
Whoa, whoa, whoa!
Hang on a second.

733
00:41:59,317 --> 00:42:00,686
You have to
change his mind.

734
00:42:00,752 --> 00:42:02,654
They want superstars,

735
00:42:02,721 --> 00:42:06,124
breast cancer specialists
who've run these big clinical
tests before. You haven't.

736
00:42:06,191 --> 00:42:07,559
Come on. You need me.

737
00:42:07,626 --> 00:42:10,461
This isn't just me
protecting my turf here.

738
00:42:10,528 --> 00:42:13,732
This is me protecting
everything we've worked for.

739
00:42:15,333 --> 00:42:16,534
There are three
arms of the study.

740
00:42:16,602 --> 00:42:18,269
San Francisco,
New York, Los Angeles.

741
00:42:18,336 --> 00:42:20,739
I'll go back to him,
see if I can get him
to give you LA.

742
00:42:20,806 --> 00:42:22,507
I've already set up
a network of doctors

743
00:42:22,574 --> 00:42:24,776
who're gonna refer
their patients to me,
so tell him that.

744
00:42:24,843 --> 00:42:26,645
Keep screening
for participants.

745
00:42:26,712 --> 00:42:28,614
I'll see what I can do.

746
00:42:33,985 --> 00:42:36,021
Hello.
Barbara Bradfield?

747
00:42:36,087 --> 00:42:38,690
Yes.
Yes, this is
Dr. Slamon at UCLA.

748
00:42:38,757 --> 00:42:41,492
I'd like to talk
to you about joining
the HER-2 Trial.

749
00:42:41,559 --> 00:42:43,328
What's HER

750
00:42:43,394 --> 00:42:46,832
It's an experimental
drug. Dr. Brown
sent me your slides.

751
00:42:47,899 --> 00:42:49,300
Right.

752
00:42:49,367 --> 00:42:52,103
Thanks, but we're leaving
in the morning for Mexico.

753
00:42:52,170 --> 00:42:54,372
I'm trying a food cure.

754
00:42:54,439 --> 00:42:56,541
All due respect...
I'm not expecting a cure,

755
00:42:56,608 --> 00:43:00,345
just some quality
time with my family.

756
00:43:00,411 --> 00:43:03,248
Ms. Bradfield, if you'd
just delay your trip
for a day I think I can...

757
00:43:03,314 --> 00:43:06,251
Does this trial
involve chemo?

758
00:43:06,852 --> 00:43:08,253
Some, yes.

759
00:43:08,319 --> 00:43:10,388
I'm not interested.

760
00:43:10,455 --> 00:43:13,859
I refuse to die bald
and throwing up.

761
00:43:13,925 --> 00:43:15,827
Good luck with your study.

762
00:43:17,228 --> 00:43:19,164
Good luck to you, too.

763
00:43:24,469 --> 00:43:26,738
Slamon.
You're back in.

764
00:43:26,805 --> 00:43:28,506
LA is yours.
Reinhardt signed off?

765
00:43:28,573 --> 00:43:32,443
Yeah. Now, go home
and get some rest.
You're going to need it.

766
00:43:33,244 --> 00:43:35,947
Yes! Yes!

767
00:43:36,014 --> 00:43:38,083
Once again,
Blake saves the day.

768
00:43:38,149 --> 00:43:39,918
Oh, God.

769
00:43:40,518 --> 00:43:42,053
I owe him big time.

770
00:43:42,120 --> 00:43:43,354
Hmm.

771
00:43:43,421 --> 00:43:44,790
How was your day?

772
00:43:45,824 --> 00:43:47,893
Good.

773
00:43:47,959 --> 00:43:49,661
Did you
find anyone?

774
00:43:49,728 --> 00:43:52,931
One woman, best candidate
I've ever seen.

775
00:43:52,998 --> 00:43:54,966
She's not
interested, though.

776
00:43:55,033 --> 00:43:56,968
Going to Mexico
for a food cure.

777
00:43:57,035 --> 00:43:59,104
There's a misnomer for you.

778
00:43:59,170 --> 00:44:00,739
Did you talk to her?

779
00:44:00,806 --> 00:44:03,574
As much as I could.
She's looking at
the end of her life,

780
00:44:03,641 --> 00:44:06,211
so how she spends
that time is her call.

781
00:44:06,277 --> 00:44:09,314
But, you know, I can't get
over the feeling I might be
able to help her.

782
00:44:09,380 --> 00:44:12,517
And selfishly,
it's bad for the study
because I get 15 women

783
00:44:12,583 --> 00:44:15,887
and I need to
make them all count.
So, I don't know.

784
00:44:19,725 --> 00:44:20,792
Hey.

785
00:44:23,661 --> 00:44:27,098
It's not always
gonna be like this,
these crazy hours.

786
00:44:29,267 --> 00:44:32,603
Yes, it will.
But that's okay.

787
00:44:34,172 --> 00:44:35,841
We just miss you.

788
00:45:01,532 --> 00:45:02,600
Hello?

789
00:45:02,667 --> 00:45:04,602
Hello, Barbara,
this is Dr. Slamon.

790
00:45:04,669 --> 00:45:09,240
I'm sorry to be calling
this early. Barbara,
don't go to Mexico.

791
00:45:09,307 --> 00:45:11,209
It's a death sentence.

792
00:45:13,111 --> 00:45:15,346
I think I can
save your life.

793
00:45:39,437 --> 00:45:42,640
* The moment I wake up

794
00:45:42,707 --> 00:45:46,211
* Before I put on my makeup

795
00:45:46,277 --> 00:45:49,915
* I say a little prayer
for you

796
00:45:49,981 --> 00:45:53,351
* While combing my hair now

797
00:45:53,418 --> 00:45:56,855
* And wondering
what dress to wear now

798
00:45:56,922 --> 00:46:00,058
* I say a little prayer
for you

799
00:46:00,125 --> 00:46:02,894
* Forever, forever,
you'll stay in my heart

800
00:46:02,961 --> 00:46:04,495
* And I will love you

801
00:46:04,562 --> 00:46:07,232
* Forever and ever,
we never will part

802
00:46:07,298 --> 00:46:08,934
* Oh, how I love you

803
00:46:09,000 --> 00:46:11,536
* Together, together,
that's how it must be

804
00:46:11,602 --> 00:46:13,304
* To live without you

805
00:46:13,371 --> 00:46:16,842
* Would only mean
heartbreak for me

806
00:46:18,977 --> 00:46:22,080
* I run for the bus, dear

807
00:46:22,147 --> 00:46:25,716
* While riding,
I think of us, dear

808
00:46:25,783 --> 00:46:29,554
* I say a little prayer
for you

809
00:46:29,620 --> 00:46:32,824
* At work,
I just take time

810
00:46:32,891 --> 00:46:36,261
* And all through
my coffee-break time

811
00:46:36,327 --> 00:46:39,497
* I say a little prayer
for you

812
00:46:39,564 --> 00:46:42,200
* Forever, forever,
you'll stay in my heart

813
00:46:42,267 --> 00:46:43,935
* And I will love you

814
00:46:44,002 --> 00:46:46,872
* Forever and ever,
we never will part

815
00:46:46,938 --> 00:46:48,306
* Oh, how I love you

816
00:46:48,373 --> 00:46:52,077
* Together, together,
that's how it must be... *

817
00:46:52,143 --> 00:46:53,544
They're all here.
All 15?

818
00:46:53,611 --> 00:46:57,282
All 15. So, as we say
in show business,

819
00:46:57,348 --> 00:46:58,516
break a leg.

820
00:46:58,583 --> 00:46:59,784
DENNY: I'll see
you out there.

821
00:46:59,851 --> 00:47:02,220
Oh! No. I have
another ball to plan.

822
00:47:02,287 --> 00:47:04,389
You can take this from here.

823
00:47:04,455 --> 00:47:07,825
Hey, Lilly.
I just wanted to say,

824
00:47:07,893 --> 00:47:11,796
you know, without you,
this would...

825
00:47:11,863 --> 00:47:14,966
Thank you.
I really mean it.
Thank you so much.

826
00:47:18,003 --> 00:47:19,137
Good morning.

827
00:47:19,204 --> 00:47:20,705
ALL: Good morning.

828
00:47:20,771 --> 00:47:22,840
Welcome to the
Phase One kickoff party.

829
00:47:22,908 --> 00:47:24,976
I'm very happy
to see all of you.

830
00:47:25,043 --> 00:47:27,778
Not as happy as
we are to see you.

831
00:47:27,845 --> 00:47:30,648
So, the drug you'll be
taking finally has a name,

832
00:47:30,715 --> 00:47:34,352
Herceptin, which is
a combination of "Her"
from HER-2,

833
00:47:34,419 --> 00:47:37,555
and "ceptin" from intercept,
which is what the drug
is designed to do,

834
00:47:37,622 --> 00:47:41,026
to intercept growth
signals from reaching
the cancer cells

835
00:47:41,092 --> 00:47:43,895
so they don't grow.
It's pretty simple
when you think about it.

836
00:47:43,962 --> 00:47:45,363
Now, for the next
three months,

837
00:47:45,430 --> 00:47:47,432
we'll be meeting here
every Tuesday at 9:00

838
00:47:47,498 --> 00:47:50,768
for the infusion
and a checkup to
monitor your progress.

839
00:47:50,835 --> 00:47:53,071
First two weeks, you'll
be receiving cisplatin,

840
00:47:53,138 --> 00:47:55,240
a traditional
chemotherapy drug.

841
00:47:55,306 --> 00:47:57,508
Every third week,
you'll get the Herceptin.

842
00:47:57,575 --> 00:47:59,978
Now, since cisplatin
is a chemotherapy,

843
00:48:00,045 --> 00:48:03,014
you'll have the traditional
side effects like fatigue
and nausea.

844
00:48:03,081 --> 00:48:06,451
But on the weeks you
receive the Herceptin,
you'll feel great.

845
00:48:06,517 --> 00:48:07,852
No side effects.

846
00:48:07,919 --> 00:48:12,723
Finally, I want
to thank all of you
so much for coming here.

847
00:48:12,790 --> 00:48:17,562
I appreciate your
hope and your belief
and your sacrifice.

848
00:48:18,696 --> 00:48:19,965
Thank you.

849
00:48:20,031 --> 00:48:21,666
I don't take that lightly.

850
00:48:24,602 --> 00:48:26,771
Okay, any questions
before we begin?

851
00:48:26,837 --> 00:48:28,706
Yeah, I do. Just one.

852
00:48:29,840 --> 00:48:32,277
I hope everybody
here is hungry.

853
00:48:37,382 --> 00:48:41,386
I know. The baker was gay,
so he hadn't seen boobs
in a while.

854
00:48:43,321 --> 00:48:46,824
My nipples aren't
black like that.
Well, they're not.

855
00:48:50,962 --> 00:48:54,065
* I say a little prayer
for you

856
00:48:54,132 --> 00:48:56,867
* Forever, forever,
you'll stay in my heart

857
00:48:56,934 --> 00:48:58,503
* And I will love you

858
00:48:58,569 --> 00:49:01,206
* Forever and ever,
we never will part

859
00:49:01,272 --> 00:49:02,907
* Oh, how I love you

860
00:49:02,974 --> 00:49:05,676
* Together, together,
that's how it must be

861
00:49:05,743 --> 00:49:07,278
* To live without you

862
00:49:07,345 --> 00:49:10,781
* Would only mean
heartbreak for me *

863
00:49:15,220 --> 00:49:17,188
ELIZABETH: Dr. Slamon.

864
00:49:17,255 --> 00:49:19,890
I'm late for a consult.
You'll have to call my office.

865
00:49:19,957 --> 00:49:21,892
Please. I drove
three hours to see you.

866
00:49:21,959 --> 00:49:23,861
You'll have to make
an appointment.
I'm sorry.

867
00:49:23,928 --> 00:49:27,465
My daughter participated in
the Mouse Protein Experiment,

868
00:49:27,532 --> 00:49:29,300
Nicole Wilson?

869
00:49:29,367 --> 00:49:32,003
Nicole, right.
Miss Mouse Ears.
She was the very first one.

870
00:49:32,070 --> 00:49:36,374
Yes, exactly. Well,
her doctor told us you're
testing your new drug.

871
00:49:36,441 --> 00:49:38,143
Right.
I'd like you to include her.

872
00:49:38,209 --> 00:49:40,911
Believe me, I would
if I could, but she just
doesn't meet the criteria.

873
00:49:40,978 --> 00:49:44,015
Well, nonsense.
She's a perfect candidate.

874
00:49:44,082 --> 00:49:46,317
One shot kept her
alive for two years.

875
00:49:46,384 --> 00:49:48,286
I'm sorry, Miss...
Aldredge.

876
00:49:48,353 --> 00:49:50,121
Ms. Aldredge, right.
But the eligibility
requirements are very strict.

877
00:49:50,188 --> 00:49:51,556
Well, then don't
put her in it.

878
00:49:51,622 --> 00:49:53,358
Just give her the drug.

879
00:49:53,424 --> 00:49:55,826
The FDA accounts
for every dose.
I'm very sorry.

880
00:49:55,893 --> 00:49:58,196
My daughter is dying!

881
00:49:58,263 --> 00:50:00,531
You have the power
to save her.

882
00:50:01,166 --> 00:50:02,400
I don't.

883
00:50:04,469 --> 00:50:07,472
I'm sorry, Mrs. Aldredge.
I do understand what you're
going through, but...

884
00:50:07,538 --> 00:50:10,075
Have you lost
a child, Dr. Slamon?

885
00:50:12,310 --> 00:50:15,513
Then don't presume to know
what I'm going through.

886
00:50:18,416 --> 00:50:21,286
I promised my husband
as he lay dying

887
00:50:21,352 --> 00:50:23,954
that I would take care
of our little girl.

888
00:50:24,021 --> 00:50:26,191
For 24 years,
I have kept that promise,

889
00:50:26,257 --> 00:50:29,527
and you will not
stand in my way
of keeping it now.

890
00:50:31,929 --> 00:50:33,598
I can't help you.

891
00:50:34,965 --> 00:50:36,901
Then get your superior
out here immediately.

892
00:50:36,967 --> 00:50:38,303
There is no superior.

893
00:50:38,369 --> 00:50:40,538
It's my study and I
don't have a choice.

894
00:50:40,605 --> 00:50:44,642
If I break the rules,
they're going
to shut it down.

895
00:50:44,709 --> 00:50:49,214
She's only 28.
She has two little boys.

896
00:50:50,848 --> 00:50:54,119
She's all I've got,
Dr. Slamon.

897
00:50:55,086 --> 00:50:57,355
Please don't
take her from me.

898
00:50:58,689 --> 00:51:02,427
Please help me.
I can't lose her, too.

899
00:51:03,694 --> 00:51:06,397
MAN: Dr. Slamon,
we need you right now, sir.

900
00:51:11,269 --> 00:51:12,803
I'm very sorry.

901
00:51:43,301 --> 00:51:44,369
Hey.

902
00:51:46,437 --> 00:51:47,505
Hi, Daddy.

903
00:51:47,572 --> 00:51:48,639
Hi.

904
00:51:51,008 --> 00:51:54,345
Will you show me
that picture that
you drew for me?

905
00:51:56,481 --> 00:51:58,683
I just really
want to see it.

906
00:51:59,984 --> 00:52:01,452
Okay, Daddy.

907
00:52:08,926 --> 00:52:11,529
You know, Barbara,
maybe this week
will be better.

908
00:52:11,596 --> 00:52:13,731
Maybe the chemo won't
make you so sick.

909
00:52:13,798 --> 00:52:16,501
Well, that would be nice,
but I don't think
it's in the cards.

910
00:52:16,567 --> 00:52:19,404
Hey. You never know.

911
00:52:19,470 --> 00:52:22,807
If I could just get home,
I wouldn't care.

912
00:52:22,873 --> 00:52:26,911
Really? You don't like
puking your guts out into
your purse at the mall?

913
00:52:26,977 --> 00:52:28,546
Must you be so graphic?

914
00:52:28,613 --> 00:52:29,914
Well, I'm just being real.

915
00:52:29,980 --> 00:52:32,082
I mean, that's really
what it is, right?

916
00:52:32,149 --> 00:52:35,853
I mean, nothing's
more real than this,
this and puking.

917
00:52:37,755 --> 00:52:40,525
And it really does just
cut through all the crap.

918
00:52:40,591 --> 00:52:42,327
Yeah, well, next week
will be better.

919
00:52:42,393 --> 00:52:44,962
We get the Herceptin.
No side effects.

920
00:52:45,029 --> 00:52:46,063
Yay!

921
00:52:46,130 --> 00:52:47,798
No, I am so ready.

922
00:52:49,667 --> 00:52:51,168
Do you hear that, cancer?

923
00:52:51,236 --> 00:52:52,637
You're going down.

924
00:52:55,573 --> 00:52:57,808
You make this
all worthwhile.

925
00:52:58,376 --> 00:52:59,610
Sorry.

926
00:53:04,582 --> 00:53:05,950
Hold on a sec.

927
00:53:06,016 --> 00:53:08,653
What? Well,
what are you doing?

928
00:53:11,155 --> 00:53:15,159
It's been months.
I want to see you.

929
00:53:15,226 --> 00:53:18,696
You want to see a scar?
You're a freak.

930
00:53:18,763 --> 00:53:24,001
I love every inch of you,
including the breast
that isn't there.

931
00:53:26,371 --> 00:53:30,007
Sex with me in the dark,

932
00:53:30,074 --> 00:53:33,744
or sex by yourself
with the light on,
your choice.

933
00:53:39,850 --> 00:53:41,352
How about a flashlight?

934
00:53:43,087 --> 00:53:44,855
Come here.
Come here.

935
00:53:57,968 --> 00:53:59,770
Does that hurt?
No.

936
00:54:03,808 --> 00:54:06,644
I just, I don't know,
like looking at it.

937
00:54:07,778 --> 00:54:10,581
Just reminds you
that you're sick.

938
00:54:10,648 --> 00:54:14,251
I don't need a stinking tumor
to remind me that I'm sick.

939
00:54:14,319 --> 00:54:16,721
Let's think good
thoughts today, Tish.

940
00:54:16,787 --> 00:54:18,923
Positive energy
creates healing.

941
00:54:21,526 --> 00:54:26,431
Wow. Is that what
I've been doing wrong
my whole life?

942
00:54:26,497 --> 00:54:30,601
Tina, do you have
an herb for that with
some aromatherapy?

943
00:54:30,668 --> 00:54:33,538
No, but we could do
some guided meditation.

944
00:54:33,604 --> 00:54:35,005
That's just too
complicated for me.

945
00:54:35,072 --> 00:54:36,173
Good morning.

946
00:54:36,240 --> 00:54:37,308
ALL: Good morning.

947
00:54:37,375 --> 00:54:39,410
Okay, so after
two weeks of chemo,

948
00:54:39,477 --> 00:54:41,379
who's ready for their
first dose of Herceptin?

949
00:54:41,446 --> 00:54:42,780
ALL: I am!
Me!

950
00:54:42,847 --> 00:54:45,149
Okay. All right,
let's start with you, Sally.

951
00:54:45,215 --> 00:54:46,951
Sally?

952
00:54:47,017 --> 00:54:48,486
How's that cough?

953
00:54:48,553 --> 00:54:49,687
It's almost gone.

954
00:54:49,754 --> 00:54:51,188
That's good.

955
00:54:58,062 --> 00:54:59,864
It's yellow.

956
00:54:59,930 --> 00:55:01,231
All right.

957
00:55:04,201 --> 00:55:05,870
I'm gonna get
more than you.

958
00:55:10,541 --> 00:55:14,011
Hey, Dr. Slamon.
It's Fran Visco,

959
00:55:14,078 --> 00:55:16,347
President of the National
Breast Cancer Coalition.

960
00:55:16,414 --> 00:55:18,516
Yeah, I remember you.
You gave me a grant.

961
00:55:18,583 --> 00:55:21,419
You were one of the very few.
Hey, do you mind walking?

962
00:55:21,486 --> 00:55:23,988
I have a patient.
Oh, not at all.

963
00:55:24,054 --> 00:55:25,423
Wow, you have
a good memory.

964
00:55:25,490 --> 00:55:27,758
That was over
eight years ago.

965
00:55:29,960 --> 00:55:31,629
You know, I've been
getting a lot of calls,

966
00:55:31,696 --> 00:55:36,066
and I know you can't
really speak about it,
but how's Phase One going?

967
00:55:36,133 --> 00:55:37,535
A lot of calls?

968
00:55:37,602 --> 00:55:40,037
Yeah, the breast
cancer community
is very tight-knit,

969
00:55:40,104 --> 00:55:41,439
and so they talk.

970
00:55:41,506 --> 00:55:43,207
Off the record,
it's going well.

971
00:55:43,273 --> 00:55:44,575
So there will be
a Phase Two?

972
00:55:44,642 --> 00:55:46,711
Off the record, yes.

973
00:55:46,777 --> 00:55:50,481
Good. Before you start
planning Phase Three,
call me.

974
00:55:50,548 --> 00:55:52,950
You're gonna need
a perspective that
those scientists

975
00:55:53,017 --> 00:55:55,520
who haven't been
through that cancer mill
don't have themselves.

976
00:55:55,586 --> 00:55:57,021
Thank you, Fran.
And I will call you.

977
00:55:57,087 --> 00:56:00,491
So, I bought this to
boost our immune systems.

978
00:56:00,558 --> 00:56:03,428
You mix it once
a day in hot water,

979
00:56:03,494 --> 00:56:05,863
and you drink it down,
just like tea.

980
00:56:05,930 --> 00:56:08,566
What is it?
Dried sea horses.

981
00:56:08,633 --> 00:56:10,468
Sally's late again.

982
00:56:10,535 --> 00:56:12,803
Forget the cancer.
This'll kill me right here.

983
00:56:14,271 --> 00:56:17,675
You know,
I know I'm always
joking with you,

984
00:56:17,742 --> 00:56:21,145
but I swear to God,
your tumor has shrunk.

985
00:56:21,211 --> 00:56:23,080
It has, hasn't it?
It is, right?
It has.

986
00:56:23,147 --> 00:56:24,214
Let me see.
Let me see.

987
00:56:24,281 --> 00:56:25,716
Look.

988
00:56:25,783 --> 00:56:28,486
Oh, my God.
It's shrunk!

989
00:56:30,488 --> 00:56:34,258
Now, Tina, I know
you didn't have time
to leave the hospital

990
00:56:34,324 --> 00:56:37,562
and go find some sea horses.
What is this?

991
00:56:37,628 --> 00:56:40,431
I mean, that came out
of the back of a dog.

992
00:56:40,498 --> 00:56:41,899
No, it did.

993
00:56:45,235 --> 00:56:48,873
Sally passed away
this morning.

994
00:56:48,939 --> 00:56:52,810
Not from the drug,
but as a result of
her advanced cancer.

995
00:56:55,880 --> 00:56:58,415
Carol will be in
to get you started.

996
00:57:18,736 --> 00:57:20,337
I'm all right.

997
00:57:20,404 --> 00:57:22,206
It wasn't your fault.

998
00:57:22,272 --> 00:57:23,841
Her death, no.

999
00:57:25,209 --> 00:57:27,111
What happens next,
though, that's all me.

1000
00:57:27,177 --> 00:57:28,779
What's all you?

1001
00:57:28,846 --> 00:57:32,950
I put them all in one room,
so they wouldn't feel alone.

1002
00:57:33,017 --> 00:57:35,820
Now they'll know
when one of them dies.

1003
00:57:35,886 --> 00:57:38,088
Great planning.

1004
00:57:38,155 --> 00:57:39,389
You couldn't have known.

1005
00:57:39,456 --> 00:57:41,692
But I should have.

1006
00:57:41,759 --> 00:57:44,194
Every single one of them
has stage-four cancer.

1007
00:57:44,261 --> 00:57:46,330
Some of them are
lucky to be alive.

1008
00:57:46,396 --> 00:57:48,933
I chose the room,
the chairs, the program.

1009
00:57:52,036 --> 00:57:56,306
I just spent so much time
trying to get it right.

1010
00:57:56,373 --> 00:57:58,909
You didn't know.
Next time you will.

1011
00:58:00,511 --> 00:58:03,413
Tell that to the women
who are looking
at the empty chair.

1012
00:59:01,005 --> 00:59:04,341
Kate! Turn down
the music.

1013
00:59:10,815 --> 00:59:13,417
What are you
doing here?

1014
00:59:13,483 --> 00:59:14,585
Oh.

1015
00:59:16,587 --> 00:59:18,956
I was in
the neighborhood,

1016
00:59:19,023 --> 00:59:22,192
thought I'd fall by,
see if you want to go
to Vegas this weekend.

1017
00:59:22,259 --> 00:59:24,128
And while we're there,

1018
00:59:26,096 --> 00:59:27,531
get married.

1019
00:59:31,602 --> 00:59:32,603
Ellie.

1020
00:59:32,670 --> 00:59:34,038
Josh.

1021
00:59:34,104 --> 00:59:37,875
I told you,
marriage is about
happily ever after,

1022
00:59:37,942 --> 00:59:40,611
and I don't know that
that applies to me.

1023
00:59:40,678 --> 00:59:42,579
Maybe the cancer's gone.

1024
00:59:42,647 --> 00:59:46,951
Not the cancer, my cancer.
And, yes, it's gone,

1025
00:59:47,017 --> 00:59:48,452
but it can come back.

1026
00:59:48,518 --> 00:59:51,155
If it does,
we'll deal with it.

1027
00:59:56,093 --> 00:59:59,864
I love you, baby,
but I can't marry you.

1028
01:00:09,807 --> 01:00:11,275
You really mean that.

1029
01:00:11,341 --> 01:00:13,310
But it doesn't
change anything.

1030
01:00:16,213 --> 01:00:21,051
For you.
Me, I want a future.

1031
01:00:23,754 --> 01:00:26,223
No matter how long
that might be.

1032
01:00:42,039 --> 01:00:46,543
I know it's bad news
or you would have
told me on the phone.

1033
01:00:46,610 --> 01:00:48,846
Well, actually,
the news is good.

1034
01:00:48,913 --> 01:00:51,548
Your response
to the Herceptin
is more successful

1035
01:00:51,615 --> 01:00:53,517
than I ever
thought possible.

1036
01:00:53,583 --> 01:00:57,387
It not only
stopped your tumor
from growing, Barbara,

1037
01:00:57,454 --> 01:00:59,323
it made it disappear.

1038
01:01:02,292 --> 01:01:03,961
My tumor's gone?

1039
01:01:04,028 --> 01:01:05,395
Your tumor's gone.

1040
01:01:06,697 --> 01:01:09,066
Now, you still have cancer,

1041
01:01:09,133 --> 01:01:13,337
but this is
an exceptional result,
amazing, even.

1042
01:01:25,315 --> 01:01:26,784
I'm sorry, I was...

1043
01:01:27,752 --> 01:01:31,756
I was expecting the worst.

1044
01:01:31,822 --> 01:01:34,324
Well, it's nice to get
some good news for a change.

1045
01:01:34,391 --> 01:01:36,160
Yeah.

1046
01:01:36,226 --> 01:01:38,662
Now, here's where we are.
We're almost done
with Phase One,

1047
01:01:38,729 --> 01:01:41,065
and I'm inviting you
to continue treatment
in Phase Two.

1048
01:01:41,131 --> 01:01:43,467
Whatever you say,
I'm there.
Good.

1049
01:01:43,533 --> 01:01:48,105
Now, you're gonna have
to sit tight for about
six weeks until we begin.

1050
01:01:48,172 --> 01:01:51,008
But I'll still be
getting my Herceptin?

1051
01:01:51,075 --> 01:01:52,943
No.

1052
01:01:53,010 --> 01:01:55,412
I can't give it
outside of the study.

1053
01:01:55,479 --> 01:01:58,749
That's FDA rules.
We have to apply
to begin Phase Two.

1054
01:01:58,816 --> 01:02:01,585
Don't worry, now.
It's just a formality.

1055
01:02:02,419 --> 01:02:04,288
What if my tumor
comes back?

1056
01:02:04,354 --> 01:02:07,958
If it does, I don't think
it's gonna grow fast
enough to be a danger.

1057
01:02:08,025 --> 01:02:12,096
And once you start
the Herceptin again,
it'll shrink. It'll be fine.

1058
01:02:14,865 --> 01:02:17,701
I have to ask you
not to tell the others.

1059
01:02:20,270 --> 01:02:23,740
Not all of them are gonna
be continuing to Phase Two.

1060
01:02:25,109 --> 01:02:27,044
Who's not coming?

1061
01:02:27,111 --> 01:02:29,146
I need to tell them first.

1062
01:02:30,047 --> 01:02:31,281
Yeah.

1063
01:02:33,150 --> 01:02:34,785
Yeah, of course.

1064
01:02:37,822 --> 01:02:42,359
Fresh from my garden.
Echinacea, for colds.

1065
01:02:42,426 --> 01:02:44,028
Works like a charm.

1066
01:02:44,094 --> 01:02:45,262
Thank you.

1067
01:02:47,431 --> 01:02:51,201
I know I'm here for
my official results,
but I already know.

1068
01:02:52,469 --> 01:02:55,372
Dr. Slamon,
I feel so much stronger.

1069
01:02:55,439 --> 01:02:57,274
You are doing better.

1070
01:03:00,277 --> 01:03:01,378
But?

1071
01:03:03,347 --> 01:03:04,949
I'm sorry, Tina.

1072
01:03:06,516 --> 01:03:09,086
You won't be
moving on to Phase Two.

1073
01:03:11,188 --> 01:03:13,757
Not moving on?

1074
01:03:13,824 --> 01:03:16,560
But you said last
week I was improving.

1075
01:03:17,727 --> 01:03:19,163
And you are.

1076
01:03:21,498 --> 01:03:25,669
But for the study,
for its ultimate success,

1077
01:03:25,735 --> 01:03:28,738
I've been given a set
of standards by the FDA.

1078
01:03:31,341 --> 01:03:32,943
I need to narrow
the group down

1079
01:03:33,010 --> 01:03:37,114
to the ones who are having
the most clear and
measurable response.

1080
01:03:37,181 --> 01:03:38,648
That's me.

1081
01:03:38,715 --> 01:03:42,152
I've gained weight,
and I'm not in pain
at all anymore.

1082
01:03:42,219 --> 01:03:43,687
You can see that.

1083
01:03:43,753 --> 01:03:44,855
I know that.

1084
01:03:46,390 --> 01:03:50,227
But the goal,
and we talked about this,

1085
01:03:51,896 --> 01:03:54,398
has been to get
Herceptin approved.

1086
01:03:56,066 --> 01:04:00,070
Now, in my heart,
I want you
to continue, Tina.

1087
01:04:00,137 --> 01:04:03,373
But in science,
it comes down
to the numbers.

1088
01:04:03,440 --> 01:04:06,476
And for the next phase,

1089
01:04:06,543 --> 01:04:10,047
and I'm sorry,
but your numbers,
they're not high enough.

1090
01:04:10,114 --> 01:04:13,383
Please.
Please, Dr. Slamon.

1091
01:04:14,952 --> 01:04:18,989
I have three children
and a husband.

1092
01:04:20,790 --> 01:04:26,330
Look, we'll pay
whatever it costs,
and nobody has to know.

1093
01:04:28,532 --> 01:04:30,467
I wish I could do that.

1094
01:04:33,670 --> 01:04:34,905
I can't.

1095
01:04:40,144 --> 01:04:43,080
I've never begged for
anything in my life.

1096
01:04:46,083 --> 01:04:49,753
But I'm begging you,
Doctor, for my life.

1097
01:04:52,256 --> 01:04:55,459
I'm sorry, for you,

1098
01:04:57,894 --> 01:04:59,997
for your family,
I'm sorry.

1099
01:05:09,473 --> 01:05:14,211
Sorry. How many...
How many lucky ones?

1100
01:05:15,912 --> 01:05:17,047
Five.

1101
01:05:18,882 --> 01:05:21,551
Well, I am happy for them.

1102
01:05:25,155 --> 01:05:26,823
Thank you, Doctor.

1103
01:05:46,143 --> 01:05:47,711
How could you do that?

1104
01:05:47,777 --> 01:05:49,179
It's part of my job.

1105
01:05:50,214 --> 01:05:53,283
You just sent
her home to die.

1106
01:05:54,751 --> 01:05:56,586
That's how it works.

1107
01:05:58,955 --> 01:06:00,557
That's not fair.

1108
01:06:01,291 --> 01:06:02,859
No, it's not.

1109
01:06:03,693 --> 01:06:05,629
That's not right.

1110
01:06:05,695 --> 01:06:08,298
It's not a question
of right or wrong.

1111
01:06:12,136 --> 01:06:14,704
I don't think
I can do this anymore.

1112
01:06:18,875 --> 01:06:20,377
But we will.

1113
01:07:06,823 --> 01:07:09,326
We have to stop
meeting like this.

1114
01:07:09,393 --> 01:07:10,627
Fran, what are
you doing here?

1115
01:07:10,694 --> 01:07:12,629
Oh, I was speaking
to a group of nurses.

1116
01:07:12,696 --> 01:07:15,632
And you? Yeah,
that's right.
You work here.

1117
01:07:15,699 --> 01:07:19,136
Hey. You were
supposed to call me
about Phase Three.

1118
01:07:19,203 --> 01:07:22,539
And I will,
as soon as I hear
that we're moving on.

1119
01:07:22,606 --> 01:07:23,973
We just finished Phase Two.

1120
01:07:24,040 --> 01:07:25,742
Six months ago.

1121
01:07:25,809 --> 01:07:28,245
I told you.
I'm watching.
I'm listening.

1122
01:07:28,312 --> 01:07:31,581
Trust me. When I
get the go-ahead,
I will call you.

1123
01:07:31,648 --> 01:07:33,817
I don't want to be notified.
I want to be involved.

1124
01:07:33,883 --> 01:07:35,419
I hear you
loud and clear.

1125
01:07:35,485 --> 01:07:36,953
Okay. Call.

1126
01:07:37,020 --> 01:07:39,289
Do I have a deal?
We have a deal.

1127
01:07:39,356 --> 01:07:41,125
Call! Okay.
I will.

1128
01:07:44,094 --> 01:07:45,362
I called you five times.

1129
01:07:45,429 --> 01:07:46,996
When were you
gonna call me back?

1130
01:07:47,063 --> 01:07:49,133
When I had an answer.
You just
called me yesterday.

1131
01:07:49,199 --> 01:07:51,101
Yeah, and last week
and the week before that,

1132
01:07:51,168 --> 01:07:52,836
and the month before that,
and five months before that!

1133
01:07:52,902 --> 01:07:54,104
When are we gonna
start Phase Three?

1134
01:07:54,171 --> 01:07:55,772
When Reinhart is
done designing it

1135
01:07:55,839 --> 01:07:57,641
and when the board
decides to pay for it,

1136
01:07:57,707 --> 01:07:59,209
which at this point
is not a sure thing.

1137
01:07:59,276 --> 01:08:01,145
That is ridiculous.

1138
01:08:01,211 --> 01:08:04,314
Herceptin works.
We proved it in
Phase One and Phase Two.

1139
01:08:04,381 --> 01:08:05,682
Why do I sound like
a broken record here?

1140
01:08:05,749 --> 01:08:07,584
Yes, Denny, One and Two
were successful,

1141
01:08:07,651 --> 01:08:09,719
but we still have
not proven anything!

1142
01:08:09,786 --> 01:08:11,421
That is what
Phase Three is for.

1143
01:08:11,488 --> 01:08:12,989
Acceptable clinical proof!

1144
01:08:13,056 --> 01:08:14,191
That's my point!

1145
01:08:14,258 --> 01:08:16,826
Don't yell at me!

1146
01:08:16,893 --> 01:08:19,963
Then get the board off
its overly-cautious ass
and get us the go-ahead.

1147
01:08:20,029 --> 01:08:21,631
You know what,
don't lecture me, either.

1148
01:08:21,698 --> 01:08:23,700
I'm not lecturing you, Blake.

1149
01:08:23,767 --> 01:08:26,136
For crying out loud,
how many times do we have
to go through this? I have...

1150
01:08:32,209 --> 01:08:34,411
Barbara and Dean
are waiting.

1151
01:08:44,221 --> 01:08:45,689
DENNY: Sorry I'm late.

1152
01:08:49,659 --> 01:08:52,496
I feel good. Please
don't tell me I'm not.

1153
01:08:54,231 --> 01:08:55,999
You're cancer-free.

1154
01:08:57,567 --> 01:08:59,769
What?

1155
01:08:59,836 --> 01:09:02,339
There's not one sign
of cancer in your body.

1156
01:09:02,406 --> 01:09:04,073
None.
How?

1157
01:09:04,140 --> 01:09:08,412
Part of it's the Herceptin.
The rest, I don't know.

1158
01:09:08,478 --> 01:09:10,680
But the cancer's
still there...
Barbara...

1159
01:09:10,747 --> 01:09:12,316
...it only takes one cell.
...you're cancer-free.

1160
01:09:12,382 --> 01:09:15,619
I read the results myself,
and I made them retest.

1161
01:09:18,355 --> 01:09:19,789
Cancer-free.

1162
01:09:21,358 --> 01:09:22,926
Cancer-free.

1163
01:09:26,062 --> 01:09:27,631
Free of cancer!

1164
01:09:29,132 --> 01:09:30,734
Cancer-free!

1165
01:09:37,040 --> 01:09:40,844
All I wanted to hear
were those words, and
I never thought I would!

1166
01:09:40,910 --> 01:09:43,713
And now I don't
know what to do!

1167
01:09:44,648 --> 01:09:46,149
What do I do?

1168
01:09:47,884 --> 01:09:49,686
Well, to be honest,

1169
01:09:49,753 --> 01:09:52,155
all of the other women
responded like I thought
they would,

1170
01:09:52,222 --> 01:09:56,360
they improved,
but your cancer's gone,
completely.

1171
01:09:56,426 --> 01:10:01,798
So, as for what
I would do,
just be grateful.

1172
01:10:03,800 --> 01:10:08,738
And by the way,
you don't have to
come here anymore.

1173
01:10:10,440 --> 01:10:12,208
Except to say hello.

1174
01:10:28,525 --> 01:10:30,594
Do you think
she misses us?

1175
01:10:30,660 --> 01:10:32,729
I know she does.

1176
01:10:32,796 --> 01:10:35,499
Just like we miss her.

1177
01:10:35,565 --> 01:10:36,966
Can I put it
on the tree?

1178
01:10:37,033 --> 01:10:38,968
I was just going to ask.

1179
01:10:48,512 --> 01:10:49,813
Merry Christmas.

1180
01:10:49,879 --> 01:10:50,947
Merry Christmas.

1181
01:10:51,014 --> 01:10:52,081
Merry Christmas.

1182
01:10:52,148 --> 01:10:53,317
Merry Christmas.

1183
01:10:54,250 --> 01:10:56,052
Merry Christmas, Mom.

1184
01:11:01,157 --> 01:11:03,327
Merry Christmas,
sweetheart.

1185
01:11:16,272 --> 01:11:21,478
I'm sorry. After
four years of remission,
your cancer is back.

1186
01:11:21,545 --> 01:11:25,114
The cancer has spread
to your lymph nodes
and your liver.

1187
01:11:26,249 --> 01:11:30,554
You'll need to get
your affairs in order.

1188
01:11:30,620 --> 01:11:36,926
Wow. People actually
say that. "Get your
affairs in order."

1189
01:11:46,503 --> 01:11:48,271
How long do I have?

1190
01:11:49,673 --> 01:11:51,808
Four months, maybe five.

1191
01:11:52,709 --> 01:11:54,310
How about chemo?

1192
01:11:55,412 --> 01:11:57,847
You've run that course.
I'm sorry.

1193
01:12:01,050 --> 01:12:06,923
You mean to tell me,
in this world-class
research hospital,

1194
01:12:06,990 --> 01:12:10,927
that's my only option?
How can that be?

1195
01:12:10,994 --> 01:12:15,565
Well, there is
one possibility.
It's a Phase Three Trial

1196
01:12:15,632 --> 01:12:17,467
and if approved,
it'll start soon,

1197
01:12:17,534 --> 01:12:19,903
but you have to
be HER-2 positive.

1198
01:12:19,969 --> 01:12:21,337
Am I?

1199
01:12:21,871 --> 01:12:23,272
I don't know.

1200
01:12:24,974 --> 01:12:26,142
But we'll find out.

1201
01:12:32,649 --> 01:12:34,818
Carl.
My afternoon's all booked.

1202
01:12:34,884 --> 01:12:37,687
I'll make it fast.
I just have a few ideas
about the trial design.

1203
01:12:37,754 --> 01:12:39,889
You've never designed
a drug trial before.

1204
01:12:39,956 --> 01:12:42,926
No, but I know more
about Herceptin than anyone.

1205
01:12:42,992 --> 01:12:44,327
Yeah, thank you.
I've got this
under control.

1206
01:12:44,394 --> 01:12:47,997
Come on, Carl.
Please, just hear me out.

1207
01:12:48,064 --> 01:12:52,569
To be honest, Denny,
I don't want
or need your input.

1208
01:12:54,438 --> 01:12:57,974
Look. I am the one
who's been in the trenches,

1209
01:12:58,041 --> 01:12:59,576
trying to find
the women that you need

1210
01:12:59,643 --> 01:13:01,411
to enroll in your
mess of a trial,

1211
01:13:01,478 --> 01:13:03,647
but I can't because
your requirements
are too strict.

1212
01:13:03,713 --> 01:13:05,649
In your opinion.
It's not just me.

1213
01:13:05,715 --> 01:13:08,885
Ask your "thought leaders."
You are running Phase Three
into the ground!

1214
01:13:08,952 --> 01:13:11,320
We're done here.
Okay.

1215
01:13:11,387 --> 01:13:12,456
If we could
just simplify...

1216
01:13:12,522 --> 01:13:14,290
I said we're done!

1217
01:13:14,357 --> 01:13:17,594
When is the last time
you told a patient
she was going to die?

1218
01:13:19,328 --> 01:13:24,200
Monica Stein.
Cindy Lopez. Jane Hart.
Sarah, Joan, Linda.

1219
01:13:24,267 --> 01:13:26,836
Those are just
the women that I had
to tell this week!

1220
01:13:26,903 --> 01:13:28,171
All of them are
HER-2 positive,

1221
01:13:28,237 --> 01:13:30,106
and all of them were
excluded from the trial

1222
01:13:30,173 --> 01:13:32,809
because they've
all had one too many
courses of chemo!

1223
01:13:32,876 --> 01:13:35,479
Well, it shouldn't
make a difference!

1224
01:13:38,448 --> 01:13:40,450
They should be eligible.

1225
01:14:03,039 --> 01:14:06,610
Is there room
in there for two?

1226
01:14:06,676 --> 01:14:09,078
As long as you
don't flip me over
like last time.

1227
01:14:09,145 --> 01:14:11,648
O ye of little faith.

1228
01:14:15,351 --> 01:14:19,322
There. See?
I'm not a total klutz.

1229
01:14:23,927 --> 01:14:25,261
It's over.

1230
01:14:26,996 --> 01:14:28,532
The trial's gonna fail.

1231
01:14:28,598 --> 01:14:31,434
No, it's not.
Yes, it is.

1232
01:14:31,501 --> 01:14:34,037
Reinhart's design
will see to that.

1233
01:14:37,874 --> 01:14:39,342
12 years.

1234
01:14:41,978 --> 01:14:46,315
12 years I've been
fighting it, for what?

1235
01:14:46,382 --> 01:14:49,318
A drug company that
just wishes I'd go away?

1236
01:14:52,221 --> 01:14:55,792
Promises I can't keep
to patients who
are counting on me?

1237
01:15:00,630 --> 01:15:02,599
All the time I missed

1238
01:15:04,634 --> 01:15:06,536
with you and the kids.

1239
01:15:10,006 --> 01:15:11,641
All for nothing.

1240
01:15:17,180 --> 01:15:19,348
You're my
long-distance runner.

1241
01:15:28,992 --> 01:15:31,227
You know what
you're gonna do?

1242
01:15:33,029 --> 01:15:35,064
You're gonna go to sleep,

1243
01:15:37,533 --> 01:15:39,569
and you're gonna wake up,

1244
01:15:41,638 --> 01:15:44,808
and you're gonna
fight your fight
until you win.

1245
01:15:50,747 --> 01:15:52,548
That's who you are.

1246
01:16:19,175 --> 01:16:20,910
Hello.
It took a year and a half,

1247
01:16:20,977 --> 01:16:22,612
but we're back on track.

1248
01:16:22,679 --> 01:16:24,781
Reinhart has
been transferred.

1249
01:16:24,848 --> 01:16:26,415
Wait, who's taking
his place?

1250
01:16:26,482 --> 01:16:27,884
I don't know,
but get this,

1251
01:16:27,951 --> 01:16:31,721
whoever it is
has marching orders
to save the study.

1252
01:16:31,788 --> 01:16:34,357
Can you believe it?
I'll call you later.

1253
01:16:37,160 --> 01:16:38,762
Yes!
Yeah, I'm calling to see

1254
01:16:38,828 --> 01:16:42,231
if I've been approved
for the study.

1255
01:16:42,298 --> 01:16:45,068
My name's Ellie Jackson.
No, I'll wait.

1256
01:16:54,577 --> 01:16:56,512
What do you mean,
no one's looked
at my paperwork?

1257
01:16:56,579 --> 01:16:59,515
You've had it
for two months.

1258
01:16:59,582 --> 01:17:03,419
Yes, I know it's July,
but I'm not on vacation.

1259
01:17:06,589 --> 01:17:10,059
I have to be approved
before the study starts,

1260
01:17:10,126 --> 01:17:12,729
so that I can start
on the first day.

1261
01:17:14,363 --> 01:17:17,200
Because I don't have
that many days left.

1262
01:17:20,369 --> 01:17:21,705
Thank you.

1263
01:17:27,510 --> 01:17:31,180
Okay, I'll cut to the chase.
We're trying to save
the Phase Three Trial,

1264
01:17:31,247 --> 01:17:33,950
and we don't have
enough participants,

1265
01:17:34,017 --> 01:17:36,419
and we're hoping
you can help.

1266
01:17:38,121 --> 01:17:41,257
So, let's see,
I could write
a cover letter

1267
01:17:41,324 --> 01:17:43,159
and send out
the information packets

1268
01:17:43,226 --> 01:17:45,294
to the 3,000 names
on my Rolodex

1269
01:17:45,361 --> 01:17:49,232
in exchange for which
you'll give me and another
breast cancer advocate

1270
01:17:49,298 --> 01:17:51,334
a say in the trial design.

1271
01:17:52,501 --> 01:17:53,569
Yes.

1272
01:17:53,636 --> 01:17:56,472
And compassionate
access to the drug,

1273
01:17:56,539 --> 01:17:58,942
for the women who do not
qualify for the trial.

1274
01:17:59,008 --> 01:18:00,543
We'd like to
do that, but...

1275
01:18:00,609 --> 01:18:02,779
No buts.

1276
01:18:02,846 --> 01:18:06,049
There are women
out there with no other
medical option,

1277
01:18:06,115 --> 01:18:09,652
except for
an experimental drug,
which does seem to work,

1278
01:18:09,719 --> 01:18:11,320
but they can't
have access to it.

1279
01:18:11,387 --> 01:18:16,092
And the FDA allows
compassionate access
in Phase Three studies.

1280
01:18:16,159 --> 01:18:19,929
Even so, there's
a very limited amount
of the drug available.

1281
01:18:19,996 --> 01:18:21,530
Make some more.

1282
01:18:23,566 --> 01:18:26,369
Tumor cell is sort of
blanketed by the HER-2.

1283
01:18:26,435 --> 01:18:27,971
If you would come
up with, kind of,

1284
01:18:28,037 --> 01:18:30,907
your top-three priorities,
that would help.

1285
01:18:35,511 --> 01:18:39,115
I don't have one
good slide here.
I can't believe that.

1286
01:18:41,217 --> 01:18:43,052
Come on. Let's go.

1287
01:18:45,789 --> 01:18:48,424
We got to get more
of these out. 16.

1288
01:19:18,554 --> 01:19:23,392
Hi. I'm here for
the Phase Three trial.

1289
01:19:23,459 --> 01:19:28,197
It took me all summer long,
but I just got approved.

1290
01:19:28,264 --> 01:19:31,600
Ellie Jackson. Welcome.
We're happy to have you,

1291
01:19:31,667 --> 01:19:33,069
except you're early.

1292
01:19:33,136 --> 01:19:36,205
I can just go get
a cup of coffee.

1293
01:19:36,272 --> 01:19:39,809
No, I didn't mean today.
We don't start
until next week.

1294
01:19:41,277 --> 01:19:43,046
That'll be too late.

1295
01:19:43,112 --> 01:19:45,214
It's just a week.

1296
01:19:45,281 --> 01:19:47,116
The trial was
just approved.

1297
01:19:47,183 --> 01:19:49,953
We aren't ready yet.
Come back next week.

1298
01:19:56,125 --> 01:19:58,361
I have been chasing people

1299
01:19:58,427 --> 01:20:02,131
and committees
around this hospital
for three months

1300
01:20:02,198 --> 01:20:07,803
trying to get approved
for this study,
to save my life.

1301
01:20:07,871 --> 01:20:11,607
And every time
I manage to get
somebody's attention,

1302
01:20:11,674 --> 01:20:15,478
they can't help me
because they're not ready.

1303
01:20:15,544 --> 01:20:22,485
They don't have my paperwork
or they're moving,
or they're on vacation,

1304
01:20:22,551 --> 01:20:25,989
or they're sitting at home
waiting for the cable guy.

1305
01:20:26,489 --> 01:20:28,591
I get it.

1306
01:20:28,657 --> 01:20:32,395
Life goes on.
People have jobs.

1307
01:20:33,496 --> 01:20:34,998
Things happen.

1308
01:20:36,132 --> 01:20:38,501
Well, cancer happened to me.

1309
01:20:40,904 --> 01:20:45,108
And I'll be damned
if I'm gonna die.

1310
01:20:45,174 --> 01:20:48,477
Not because there weren't
people here to help me,

1311
01:20:48,544 --> 01:20:50,880
but because
they weren't ready.

1312
01:20:54,417 --> 01:20:57,353
I'm dying in front
of you right now.

1313
01:20:58,754 --> 01:21:02,926
And if you have help
to give me, I need it now.

1314
01:21:03,659 --> 01:21:05,594
I need it right now!

1315
01:21:10,466 --> 01:21:12,201
Find Dr. Slamon.

1316
01:21:17,440 --> 01:21:18,774
Thank you.

1317
01:21:24,680 --> 01:21:27,250
Hi, Ellie. Dr. Slamon.

1318
01:21:27,316 --> 01:21:29,018
I'm sorry about
the scene out there.

1319
01:21:29,085 --> 01:21:31,354
Oh! Don't apologize.
Are you kidding?

1320
01:21:31,420 --> 01:21:34,590
Do you know how many
fits I've had to throw
around here myself?

1321
01:21:34,657 --> 01:21:36,259
It's ridiculous.

1322
01:21:39,395 --> 01:21:41,330
All right.

1323
01:21:44,900 --> 01:21:47,003
It's official.

1324
01:21:47,070 --> 01:21:50,506
You are the first
subject in Phase Three.
Congratulations.

1325
01:21:50,573 --> 01:21:52,041
Thank you, Dr. Slamon.

1326
01:21:52,108 --> 01:21:53,309
No, Ellie.

1327
01:21:54,610 --> 01:21:57,046
Thank you.

1328
01:21:57,113 --> 01:21:59,148
Carol's gonna be in
shortly, all right?

1329
01:21:59,215 --> 01:22:01,017
Okay.
Okay.

1330
01:22:15,631 --> 01:22:17,800
WOMAN OVER PA:
Congratulations,
runners and walkers,

1331
01:22:17,866 --> 01:22:20,536
you are halfway there.

1332
01:22:20,603 --> 01:22:22,171
Please visit
the water tables,

1333
01:22:22,238 --> 01:22:24,974
and we'll see you
at the finish line.

1334
01:22:28,611 --> 01:22:29,878
DONNA: Have you
seen Lilly?

1335
01:22:29,945 --> 01:22:32,381
I guess she's around
here somewhere.

1336
01:22:32,448 --> 01:22:33,816
Dr. Slamon?

1337
01:22:35,018 --> 01:22:36,885
Hi.
Hello.

1338
01:22:36,952 --> 01:22:39,522
I just wanted to
tell you, thank you.

1339
01:22:39,588 --> 01:22:43,092
Well, thank you.
Thank you.
Thank you so much.

1340
01:22:43,159 --> 01:22:47,196
Dr. Slamon. Thank you
for fighting for us.

1341
01:22:47,263 --> 01:22:48,931
All these people
know Dad?

1342
01:22:48,998 --> 01:22:51,000
Yeah, and they're
thanking him.

1343
01:22:51,067 --> 01:22:53,002
For what?

1344
01:22:53,069 --> 01:22:55,271
Helping them or
someone they love.

1345
01:22:55,338 --> 01:23:00,343
Dr. Slamon, I just wanted
to say thanks for giving
my mom more time.

1346
01:23:00,409 --> 01:23:01,544
Who's your mom?

1347
01:23:01,610 --> 01:23:03,479
Nicole Wilson.

1348
01:23:03,546 --> 01:23:06,315
Well, I think I should
be thanking you.

1349
01:23:06,382 --> 01:23:07,783
Your mother
was the first.

1350
01:23:07,850 --> 01:23:10,086
We wouldn't be
here without her.

1351
01:23:14,890 --> 01:23:18,094
Thank you, Doctor.
Thank you.
Thank you so much.

1352
01:23:22,165 --> 01:23:23,432
DENNY: Hey, buddy.

1353
01:23:27,636 --> 01:23:28,904
This is Slamon.

1354
01:23:28,971 --> 01:23:30,373
BLAKE: I'm coming
down today.

1355
01:23:30,439 --> 01:23:33,176
Meet me outside
your building at 4:30.
Don't be late.

1356
01:23:33,242 --> 01:23:34,943
Blake, why don't you
just come to my office?

1357
01:23:35,010 --> 01:23:36,512
Just be there.

1358
01:23:45,621 --> 01:23:49,058
Oh! Look, you're late.
I got a plane to catch.

1359
01:23:49,125 --> 01:23:51,260
Look, I read all
the data last night.

1360
01:23:51,327 --> 01:23:53,396
I wanted you to
hear it from me.

1361
01:23:54,330 --> 01:23:55,598
Well?

1362
01:23:55,664 --> 01:23:57,100
Congratulations.

1363
01:23:57,166 --> 01:24:00,035
We proved Herceptin
officially works.

1364
01:24:00,103 --> 01:24:03,106
More than anyone ever
imagined, except for you.

1365
01:24:05,674 --> 01:24:08,111
I got to get to DC.
I'm showing the
results to the FDA.

1366
01:24:08,177 --> 01:24:09,945
Do you need me to go?
I can go.

1367
01:24:10,012 --> 01:24:11,747
Denny, I think I can
handle this one.

1368
01:24:11,814 --> 01:24:13,349
Don't tell anyone
but Donna.

1369
01:24:13,416 --> 01:24:14,917
What about Lilly?

1370
01:24:15,518 --> 01:24:16,852
And Lilly.

1371
01:24:18,321 --> 01:24:19,988
Good work.
You, too.

1372
01:24:30,065 --> 01:24:32,034
What are you
doing home?

1373
01:24:35,804 --> 01:24:37,140
I just saw Blake.

1374
01:24:37,206 --> 01:24:39,074
Did you invite
him over for...

1375
01:25:25,288 --> 01:25:26,889
I love you, Mom.

1376
01:26:20,943 --> 01:26:22,345
All right! Yeah!

1377
01:26:24,413 --> 01:26:25,948
Yeah!

1378
01:26:37,793 --> 01:26:38,894
Run!

1379
01:26:51,707 --> 01:26:53,276
Yeah!

1380
01:26:57,513 --> 01:26:58,614
Yay!